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Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

There is no literature concerning toxicokinetics available. Some rough preliminary statements can be given based on the available studies and data.

1,2 pentanediol is a liquid with a low vapor pressure. The substance has a log Po/w of 0.06 at 20 °C and therefore is miscible with water in any ratio.

From clear substance related clinical signs in acute toxicity studies it can be concluded that 1,2 pentanediol is bioavailable via oral dermal and inhalative route.

Comparing toxicity acute toxic effects via different routes it can be concluded as a rough preliminary estimation that resorption rate is independent from the route of exposure. In example moderate respiratory distress lasting for several days was observed in rats after 4 h exposure to ca. 7 mg/L (aerosol). Supposing a 100 % resorption an internal systemic dose of 2870 mg/kg can be calculated for the rat. Dyspnoe lasting for several days was also observed in rats exposed dermally to a limit dose of 2000 mg/kg. Rats exposed orally to a limit dose of 5000 mg/kg displayed similar but more severe symptoms as dose was higher.

1,2 pentanediol may be excreted unchanged or conjugated to glucoronidate or sulphate via urine. As there is no clear hint for a first pass effect in the liver significant amount may be excreted unchanged.

Due to high water solubility and possible metabolism1,2 pentanediol is unlikely to accumulate in the body.

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