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Administrative data

Description of key information

Acute toxicity:
- oral: LD50 >5000 mg/kg bw (OECD 401)
- inhalative: LC50 >7015 mg/m3 (equivalent to OECD 403)
- dermal: LD50 > 2000 mg/kg bw (OECD 402)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
7 015 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute oral toxicity of pentane-1,2-diol has been assessed in five male and five females rats in a study performed according to OECD Guideline 401 (Ciba-Geigy Ltd, 1982). As result, the LD50 was found to be > 5000 mg/kg body weight for both, females and males.

The acute inhalative toxicity was evaluated in a study conducted equivalent to OECD guideline 403 (Ciba-Geigy Ltd, 1982). Groups of ten male and ten female rats were exposed nose-only for 4 h to an aerosol of 3380 and 7015 mg/m3 pentane-1,2-diol, respectively. Although slight dyspnoae and curved body position was observed in all animals, as well slight and moderate ruffled fur was seen in the low and high dosage group, no mortality was noted. Thus, the LC50 was found to be >7015 mg/m3 air.

The acute dermal toxicity was assessed in five male and five female rats according

to OECD Guideline 402 (Ciba-Geigy Ltd, 1982). Since no mortalities were noted at the dose level of 2000 mg/kg bw during the 14 day observation period, the LD50 was > 2000 mg/kg bw.

Justification for classification or non-classification

Due to the found LD50 values for acute oral, inhalative and dermal toxicity no classification according to EU criteria for acute toxicity is necessary.