Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Remarks:
Method written by Carpenter and Smyth in 1946.
Type of information:
experimental study
Remarks:
Method written by Carpenter and Smyth in 1946.
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
method Smyth 1962

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1993
Report date:
1962

Materials and methods

Principles of method if other than guideline:
Method written by Carpenter and Smyth in 1946. See it in the attachement page 11th of the book.
GLP compliance:
no

Test material

1
Chemical structure
Reference substance name:
Indole
EC Number:
204-420-7
EC Name:
Indole
Cas Number:
120-72-9
Molecular formula:
C8H7N
IUPAC Name:
1H-indole
Test material form:
solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Basis:
other: not specified
Time point:
24 h
Score:
>= 8
Max. score:
10
Reversibility:
not fully reversible within:
Remarks on result:
probability of severe irritation

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
H318 Eye dam 1. Causes serious eye damage.
Executive summary:

It is classifed as H318 Eye dam 1. Causes serious eye damage.