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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation, other
Remarks:
Method written by Carpenter and Smyth in 1946.
Type of information:
experimental study
Remarks:
Method written by Carpenter and Smyth in 1946.
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
method Smyth 1962

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1993
Report date:
1962

Materials and methods

Principles of method if other than guideline:
Method written by Carpenter and Smyth in 1946. See it in the attachement page 11th of the book.
GLP compliance:
no

Test material

1
Chemical structure
Reference substance name:
Indole
EC Number:
204-420-7
EC Name:
Indole
Cas Number:
120-72-9
Molecular formula:
C8H7N
IUPAC Name:
1H-indole
Test material form:
solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Basis:
other: not specified
Time point:
24 h
Score:
>= 8
Max. score:
10
Reversibility:
not fully reversible within:
Remarks on result:
probability of severe irritation

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
H318 Eye dam 1. Causes serious eye damage.
Executive summary:

It is classifed as H318 Eye dam 1. Causes serious eye damage.