Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.193
Temp.:
25 °C
pH:
4.1
Remarks on result:
other: logKow was reported to be 3.193 ± 0.001
Details on results:
The Partition coefficient (Pow) of the test chemical was determined to be 3.193 ± 0.001 at 25°C

Table:

Test substance

 

K

Log k

Log Pow by Generalized Calibration

Graph

Mean of Log Pow ± S.D.

Rt1

2.371

1.521

0.182

3.192

3.193 ± 0.001

Rt2

2.373

1.524

0.183

3.193

Conclusions:
The partition coefficient (n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°.
Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°.

Description of key information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.193
at the temperature of:
25 °C

Additional information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°C.

Based on the data obtained from various reliable sources, the octanol-water partition coefficient (log Pow) of the test chemical was determined to be 3.57.

Thus based on the above data, the log Pow was ranges from 3.193 to 3.57.