Registration Dossier
Registration Dossier
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EC number: 289-200-9 | CAS number: 86178-38-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- Mathematical simulation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Data source
Referenceopen allclose all
- Title:
- IH SkinPerm (v2.04)
- Author:
- AIHA
- Year:
- 2 018
- Bibliographic source:
- https://www.aiha.org/get-involved/VolunteerGroups/Pages/Exposure-Assessment-Strategies-Committee.aspx
- Reference Type:
- publication
- Title:
- Dermal absorption of chemicals: estimation by IH SkinPerm
- Author:
- Tibaldi R, ten Berge W, Drolet D
- Year:
- 2 014
- Bibliographic source:
- J Occup Environ Hyg.,11(1):19-31
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- IH SkinPerm mathematical tool for estimating dermal absorption
Test material
- Reference substance name:
- 3,3,5-trimethylcyclohexyl acrylate
- EC Number:
- 289-200-9
- EC Name:
- 3,3,5-trimethylcyclohexyl acrylate
- Cas Number:
- 86178-38-3
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 3,3,5-trimethylcyclohexyl prop-2-enoate
Constituent 1
- Specific details on test material used for the study:
- -Molecular weight : 196.29
-Temperature : 25°C
-Vapour pressure : 12.8 Pa (25°C)
-Water solubility = 18.3 mg/L
-Log kow = 4.6
-density = 930 mg/cm2
-melting point = -94.8 °C
Administration / exposure
- Details on in vitro test system (if applicable):
- Details of the method are available on the attached document.
Results and discussion
Percutaneous absorption
- Time point:
- 8 h
- Dose:
- 100
- Parameter:
- percentage
- Absorption:
- 0.8 %
Any other information on results incl. tables
Details of the results are available on the attached document.
Applicant's summary and conclusion
- Conclusions:
- According to the IH skin perm (QSAR), the dermal absorption of 3,3,5-trimethylcyclohexyl acrylate is 0.8%.
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