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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
grey literature
Title:
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
Author:
Mackinson et al.
Year:
1981
Bibliographic source:
DHHS(NIOSH) Publication no. 81-13 (3. VOLS) Washington DC: US Government Printing Office, Jan. 1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Propiolactone
EC Number:
200-340-1
EC Name:
Propiolactone
Cas Number:
57-57-8
Molecular formula:
C3H4O2
IUPAC Name:
oxetan-2-one

Results and discussion

In vivo

Results
Irritation parameter:
other: Permanent corneal opacification
Reversibility:
not reversible
Remarks on result:
other: Eye contact with liquid beta-propiolactone can cause permanent corneal opacification
Irritant / corrosive response data:
Eye contact with liquid beta-propiolactone can cause permanent corneal opacification

Applicant's summary and conclusion

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