Registration Dossier
Registration Dossier
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EC number: 200-340-1 | CAS number: 57-57-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology of the Eye. 2nd Edition
- Author:
- Grant
- Year:
- 1 974
- Bibliographic source:
- Charles C. Thomas, Springfield Illinois, 1974, p. 859
- Reference Type:
- grey literature
- Title:
- NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
- Author:
- Mackinson et al.
- Year:
- 1 981
- Bibliographic source:
- DHHS(NIOSH) Publication no. 81-13 (3. VOLS) Washington DC: US Government Printing Office, Jan. 1981
- Reference Type:
- publication
- Title:
- Use of the Albino Guinea-pig to detect the Skin-sensitizing ability of chemicals
- Author:
- Stevens MA
- Year:
- 1 967
- Bibliographic source:
- British Journal of industrial Methods
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- reduced LLNA
Test material
- Reference substance name:
- Propiolactone
- EC Number:
- 200-340-1
- EC Name:
- Propiolactone
- Cas Number:
- 57-57-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- oxetan-2-one
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Alderly Park
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 100 %
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- other: Erythema Rating
- Value:
- ca. 2
- Remarks on result:
- other: 2 of 6 individuals exhibit pink erythema
Any other information on results incl. tables
Skin burns in human(s) result from contact for twenty min in 40% solution in water. Exposure to beta-propiolactone ca. cause irritation and blistering of the skin, hair loss and scarring.
Applicant's summary and conclusion
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