Registration Dossier
Registration Dossier
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EC number: 200-340-1 | CAS number: 57-57-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology of the Eye. 2nd Edition
- Author:
- Grant
- Year:
- 1 974
- Bibliographic source:
- Charles C. Thomas, Springfield Illinois, 1974, p. 859
- Reference Type:
- grey literature
- Title:
- NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
- Author:
- Mackinson et al.
- Year:
- 1 981
- Bibliographic source:
- DHHS(NIOSH) Publication no. 81-13 (3. VOLS) Washington DC: US Government Printing Office, Jan. 1981
- Reference Type:
- publication
- Title:
- Use of the Albino Guinea-pig to detect the Skin-sensitizing ability of chemicals
- Author:
- Stevens MA
- Year:
- 1 967
- Bibliographic source:
- British Journal of industrial Methods
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- reduced LLNA
Test material
- Reference substance name:
- Propiolactone
- EC Number:
- 200-340-1
- EC Name:
- Propiolactone
- Cas Number:
- 57-57-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- oxetan-2-one
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Alderly Park
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 100 %
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- other: Erythema Rating
- Value:
- ca. 2
- Remarks on result:
- other: 2 of 6 individuals exhibit pink erythema
Any other information on results incl. tables
Skin burns in human(s) result from contact for twenty min in 40% solution in water. Exposure to beta-propiolactone ca. cause irritation and blistering of the skin, hair loss and scarring.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
