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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data calculated by the QSAR Toolbox.
GLP compliance:
no
Test organisms (species):
other: Danio rerio Oncorhynchus mykiss Oryzias latipes Pimephales promelas
Test type:
not specified
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
12.7 mg/L
Basis for effect:
mortality (fish)
Remarks on result:
other: Toolbox value by trend analysis
Conclusions:
The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by trend analysis using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 12.7 mg/L.
Endpoint:
short-term toxicity to fish
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data predicted by the QSAR Toolbox.
GLP compliance:
no
Test organisms (species):
other: Danio rerio Oncorhynchus mykiss Oryzias latipes Pimephales promelas
Test type:
not specified
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
7.5 mg/L
Basis for effect:
mortality (fish)
Remarks on result:
other: Toolbox value by read-across
Conclusions:
The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by read-across using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 7.5 mg/L.

Description of key information

Two predictions were performed with QSAR Toolbox, one by read-across (96h LC50: 7.5 mg/L), one by trend analysis (96 LC50: 12.7 mg/L).

As a worst case approach, 1,3 -difluorobenzene is considered as toxic for fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
7.5 mg/L

Additional information