1,3-difluorobenzene

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

other: OECD QSAR Toolbox v4.1 prediction

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

See attached justification

Qualifier:

no guideline followed

Principles of method if other than guideline:

Data calculated by the QSAR Toolbox.

GLP compliance:

no

Test organisms (species):

other: Danio rerio Oncorhynchus mykiss Oryzias latipes Pimephales promelas

Test type:

not specified

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

12.7 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Toolbox value by trend analysis

Conclusions:

The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by trend analysis using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 12.7 mg/L.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

other: OECD QSAR Toolbox v4.1 prediction

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

See attached justification

Qualifier:

no guideline followed

Principles of method if other than guideline:

Data predicted by the QSAR Toolbox.

GLP compliance:

no

Test organisms (species):

other: Danio rerio Oncorhynchus mykiss Oryzias latipes Pimephales promelas

Test type:

not specified

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

7.5 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Toolbox value by read-across

Conclusions:

The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by read-across using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 7.5 mg/L.

Description of key information

Two predictions were performed with QSAR Toolbox, one by read-across (96h LC50: 7.5 mg/L), one by trend analysis (96 LC50: 12.7 mg/L).

As a worst case approach, 1,3 -difluorobenzene is considered as toxic for fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

7.5 mg/L