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EC number: 206-746-5 | CAS number: 372-18-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: OECD QSAR Toolbox v4.1 prediction
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Data calculated by the QSAR Toolbox.
- GLP compliance:
- no
- Test organisms (species):
- other: Danio rerio
Oncorhynchus mykiss Oryzias latipes Pimephales promelas - Test type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 12.7 mg/L
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Toolbox value by trend analysis
- Conclusions:
- The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by trend analysis using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 12.7 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: OECD QSAR Toolbox v4.1 prediction
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Data predicted by the QSAR Toolbox.
- GLP compliance:
- no
- Test organisms (species):
- other: Danio rerio
Oncorhynchus mykiss Oryzias latipes Pimephales promelas - Test type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.5 mg/L
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Toolbox value by read-across
- Conclusions:
- The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by read-across using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 7.5 mg/L.
Referenceopen allclose all
Description of key information
Two predictions were performed with QSAR Toolbox, one by read-across (96h LC50: 7.5 mg/L), one by trend analysis (96 LC50: 12.7 mg/L).
As a worst case approach, 1,3 -difluorobenzene is considered as toxic for fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.5 mg/L
Additional information
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