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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification

Data source

Reference
Title:
QSAR Toolbox 4.1 prediction for LD50 read-across for 372-18-9
Year:
2017
Bibliographic source:
http://www.oecd.org/

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data calculated by the QSAR Toolbox.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-difluorobenzene
EC Number:
206-746-5
EC Name:
1,3-difluorobenzene
Cas Number:
372-18-9
Molecular formula:
C6H4F2
IUPAC Name:
1,3-difluorobenzene
Test material form:
liquid
Details on test material:
Name of the test material: 1,3-difluorobenzene
No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 790 mg/kg bw
Remarks on result:
other: Toolbox value by read-across

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 value of 1,3-difluorobenzene determined by read-across was found to be 1790 mg/kg in rats using the QSAR Toolbox.

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