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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification

Data source

Reference
Title:
QSAR Toolbox 4.1 prediction for LD50 read-across for 372-18-9
Year:
2017
Bibliographic source:
http://www.oecd.org/

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data calculated by the QSAR Toolbox.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-difluorobenzene
EC Number:
206-746-5
EC Name:
1,3-difluorobenzene
Cas Number:
372-18-9
Molecular formula:
C6H4F2
IUPAC Name:
1,3-difluorobenzene
Test material form:
liquid
Details on test material:
Name of the test material: 1,3-difluorobenzene
No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 790 mg/kg bw
Remarks on result:
other: Toolbox value by read-across

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 value of 1,3-difluorobenzene determined by read-across was found to be 1790 mg/kg in rats using the QSAR Toolbox.