1,3-difluorobenzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

other: OECD QSAR Toolbox v4.1 prediction

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

See attached justification

Data source

Reference

Title:

QSAR Toolbox 4.1 prediction for LD50 read-across for 372-18-9

Year:

2017

Bibliographic source:

http://www.oecd.org/

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Data calculated by the QSAR Toolbox.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

1,3-difluorobenzene

EC Number:

206-746-5

EC Name:

1,3-difluorobenzene

Cas Number:

372-18-9

Molecular formula:

C6H4F2

IUPAC Name:

1,3-difluorobenzene

Test material form:

liquid

Details on test material:

Name of the test material: 1,3-difluorobenzene
No data available

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1 790 mg/kg bw

Remarks on result:

other: Toolbox value by read-across

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral LD50 value of 1,3-difluorobenzene determined by read-across was found to be 1790 mg/kg in rats using the QSAR Toolbox.