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Partition coefficient

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Description of key information

The key value for the log Pow is 3.21 to 3.25 (at 20°C) although a number of other sources are reported with slighly lower values.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.25
at the temperature of:
20 °C

Additional information

A total of twelve log Pow values are reported in the five studies cited. They vary between 2.92 and 3.25 although the temperature is not indicated in most cases. These are recorded in the table below:-

Log Pow  Temperature / °C

 Reference

3.21 -3.25  20  SIDS
3.0  Not given  SIDS
 2.92   Not given  SIDS
3.06  Not given  SIDS
3.08   Not given  SIDS
 3.15   Not given  SIDS
 3.23   Not given  CRC Handbook
 3.17   Not given  International Chemical Safety Card for 2,4 -Dichorophenol
3   Not given  IUCLID Dataset 4
3.06   Not given  IUCLID Dataset 4
3.08   Not given  IUCLID Dataset 4
3.21 -3.25  20  EPA High Production Volume Information System

In accordance with the ECHA guidance document (Guidance on information requirements and chemical safety assessment, Chapter R .7a : Endpoint specific guidance - subsection 7.1.8.3, page 105) where there are variations in the values reported the highest reliable value should take precedence - hence 3.25 at 20 °C. In addition, the guidance document also references a number of additional potential data sources, one of which is the Canadian National Committee for CODATA (CNC/CODATA) database (http://logKow/cisti/nrc/ca).

This database lists 20 log Pow values ranging from 2.87 to 3.41 at 20 -25 °C (where the temperature is available) which is reproduced below :- (http://logkow.cisti.nrc.ca/logkow/display?OID=1339 ).

Log Kow

Ref

Temp

Equil Meth

Anal Meth

Aq Phase

Phases Anal

Meth Ref

Method

Footnote

2.87

1986Chia

 

 

 

 

 

 

HPLC retention time correlation

 

2.88

1993Huaa

 

SF

 

 

 

1971Leo

 

 

2.90

2002Wu

25.0

SF

AS

W

AQ

1981Oec

 

 

2.92

1982Ham

 

 

 

 

 

 

HPLC retention time correlation

 

2.97

1986Miy

 

 

 

 

 

 

HPLC retention time correlation

 

3.00

1988Ahl

 

SF

 

 

 

1981Oec

 

 

3.06

1971Sto

 

SF

AS

"acid"

both

1964Fuj

 

 

3.08

1973Yag

 

SF

AS

W

AQ

1964Fuj

 

 

3.08

1979Scha

 

 

 

 

 

 

 

 

3.12

1981But

 

 

 

 

 

 

HPLC retention time correlation

 

3.14

1982Miya

 

 

 

 

 

 

HPLC retention time correlation

 

3.17

1984Xiea

20.0

SF

GLC

"acid"

both

 

 

 

3.20

1994Kis

20.0

SF

CR/GLC

pH3-10

AQ

 

 

ion-corrected to neutral form

3.21

1988Shia

 

SF

 

W

 

 

 

 

3.23

1984Scha

20.0

SF

HPLC

pH2

AQ

 

 

 

3.23

1984Xie

 

 

 

 

 

 

HPLC retention time correlation

 

3.30

1972Mac

 

SF

 

 

 

1969Leo

 

K. Thomae, private communication

3.41

1984Bel

 

SF

AS

W

AQ

1964Fuj

 

 

3.41

1987Ter

 

 

 

 

 

 

by centrifugal partition chromatography

average value

2.98

2008Xie

25.0

SF

AS

W

AQ

 

 

 

Given that the first value (3.21 -3.25) to be reported in the SIDS dossier is regarded as a critical study for this endpoint this is taken as the key value for chemical safety assessment. Since this is a range the higher value is taken in accordance with the ECHA guidance document (Guidance on information requirements and chemical safety assessment, Chapter R .7a : Endpoint specific guidance - subsection 7.1.8.3, page 105).