Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
other: No method followed
Type of information:
other: Comment in the SIDS dossier
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The SIDS dossier does not identify a study for skin sensitisation.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
None
GLP compliance:
not specified
Remarks:
Not applicable
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichlorophenol
EC Number:
204-429-6
EC Name:
2,4-dichlorophenol
Cas Number:
120-83-2
Molecular formula:
C6H4Cl2O
IUPAC Name:
2,4-dichlorophenol
Details on test material:
Not applicable

In vivo test system

Test animals

Species:
other: Not applicable
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not applicable

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: Not applicable
Vehicle:
no data
Remarks:
Not applicable
Concentration / amount:
Not applicable
Challengeopen allclose all
Route:
other: Not applicable
Vehicle:
no data
Remarks:
Not applicable
Concentration / amount:
Not applicable
No. of animals per dose:
Not applicable
Details on study design:
Not applicable
Challenge controls:
Not applicable
Positive control substance(s):
not required
Remarks:
Not applicable

Study design: in vivo (LLNA)

Concentration:
Not applicable
No. of animals per dose:
Not applicable
Details on study design:
Not applicable
Statistics:
Not applicable

Results and discussion

Positive control results:
Not applicable

In vivo (non-LLNA)

Results
Reading:
other: Not applicable
Group:
other: Not applicable
Dose level:
Not applicable
Clinical observations:
Not applicable
Remarks on result:
other: Reading: other: Not applicable. Group: other: Not applicable. Dose level: Not applicable. Clinical observations: Not applicable.

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: Not applicable
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: Not applicable

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
No study has been identified and the skin sensitistaion potential has not been assessed since the substance is corrosive.
Executive summary:

No study was identified for skin sensitisation potential with 2,4-DCP. It may not be achievable since the substance is corrosive. In addition, the evaluation of the skin sensitisation potential may be unwanted due to the mandatory prevention of exposure. Therefore skin sensitisation potential has not been assessed. It is not considered to be prudent owing to the desire to avoid any contact with corrosive substances.

Chloracnea has been reported upon human exposure to a mixture of chlorophenols containing 2,4 -dichlorophenol.

Bleiberg J.et al(1964) Arch.Dermatol., 89: 793-797, Poland A.P.et al.(1971) Arch. Environ. Health, 22: 316-327