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EC number: 268-717-3 | CAS number: 68133-90-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.14 µg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.014 µg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 235 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.261 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.026 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.005 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
This substance is a member of the category of "Platinum(IV) substances". As such,
the data requirements for this substance are covered by relevant and reliable experimental test data generated for all members of this category via a read-across approach.
A read-across justification report and PNEC derivation report are attached in IUCLID Annex 13.
Conclusion on classification
Environmental classification for the platinum(IV) substances under consideration is based on the lowest acute and chronic threshold values from the Pt(IV) ecotoxicity test data:
-acute ERV: lowest acute threshold value is 99 µg Pt/L (geometric mean EC50 value with D. magna, based on the experimental results for hexachloroplatinic acid (n=3), dihydrogen hexahydroxoplatinate and diammonium hexachloroplatinate)
-chronic ERV: lowest chronic threshold value is 7 µg Pt/L (NOEC value (calculated as EC16/2) with D. magna, based on the experimental results for hexachloroplatinic acid.
The derivation of both ERV values is detailed in the read-across justification report (cfr. IUCLID Section 13) and PNEC derivation report (cfr. IUCLID Section 13).
For classification purposes, these ERVs have been recalculated to the values expressed as the concentration of the substance (conversion based on molecular weight conversion from soluble ion to the substance considered – cfr. details in below table). This results in a classification as Acute Category 1 and Chronic Category 1 for all substances contained in the below table. Acute and chronic M-factors are based on the value of the substance-specific acute and chronic ERV, as outlined in ECHA Guidance on the application of the CLP criteria (version 5.0; ECHA, 2017) - cfr. below table.
However, and as explained in the read-across justification document attached in IUCLID section 13, for platinum (IV) substances, there is some uncertainty related to potential observed (and currently unexplained) differences in effects thresholds observed between chloride and hydroxide coordinated Pt(IV) substances. As will be shown, under ecologically relevant conditions, they will all respeciate to a similar [Pt(OH)2]0species. However, the kinetics of this process are currently unknown.
Therefore, the approach for hazard assessment and classification considers these potential/temporal differences in toxicity due to the co-ordinating ligands: the classification is derived based on the substance specific test data and based on the test data for the category as described below. The most conservative classification will be applied.
Classification using category data | Classification using substance specific data | ||||||||||
Molecular formula | MW | Pt (wt%) | Acute ERV (µg TI/L) |
Chronic ERV (µg TI/L) |
Aq Acute classif | Aq Chron classif | Acute ERV (µg TI/L) | Chronic ERV (µg TI/L) | Aq Acute classif | Aq Chron classif | |
Diammonium hexachloroplatinate | (NH4)2[PtCl6] | 443.87 | 43.9 | 221.7 | 15.9 | Aq Acute 1, M=1 | Aq Chron 1, M=1 | 284 (Simon,2014)$ | 17 (Biesinger&Christensen,1972)$ | Aq Acute 1, M=1 | Aq Chron 1, M=1 |
Dipotassium hexachloroplatinate | K2[PtCl6] | 485.98 | 40.1 | 242.7 | 17.4 | Aq Acute 1, M=1 | Aq Chron 1, M=1 | 51 (Moll&Wydra,2005)£ | 17 (Biesinger&Christensen, 1972)£ | Aq Acute 1, M=10 | Aq Chron 1, M=10 |
Hexachloroplatinic acid | H2[PtCl6] | 409.8 | 47.6 | 204.7 | 14.7 | Aq Acute 1, M=1 | Aq Chron 1, M=1 | 60.8 (Moll&Wydra,2005)* | 14 (Biesinger&Christensen, 1972)* | Aq Acute 1, M=10 | Aq Chron 1, M=10 |
Dihydrogen hexahydroxyplatinate | H2[PtOH6] | 299.14 | 65.2 | 149.4 | 10.7 | Aq Acute 1, M=1 | Aq Chron 1, M=1 | 742 (Simon, 2014)+ | 946 (Wenzel, 2014)+ | Aq Acute 1, M=1 | Aq Chron 1, M=1 |
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | (HO-C2H4-NH3)2Pt(OH)6 | 421.3 | 46.3 | 210.4 | 15.1 | Aq Acute 1, M=1 | Aq Chron 1, M=1 | 682 (Wenzel, 2016)% | 39 (Wenzel, 2016)% | Aq Acute 1, M=1 | Aq Chron 1, M=1 |
* Environmental classification is assessed based on the lowest acute and chronic values from ecotoxicity tests performed with the substance itself. For this substance, the lowest acute value is a 48-hour EC50 of 0.0608 mg test item L-1 (0.0205 mg Pt L-1) for aquatic invertebrates(mobility) and the lowest chronic value is a 21-day NOEC value of 0.007 mg Pt L-1 (0.014 mg test item L-1) for Daphnia, based on reproduction. A full chronic dataset (fish, Daphnia and algae) is not available for this substance, therefore classification has been assessed based on both the acute and chronic data, with the worst case classification assigned. An environmental classification of Acute Category 1, Chronic Category 1 is assigned to this substance, based on the acute data. As the lowest EC50 value is >0.01 ≤ 0.1 an acute M factor of 10 is assigned. A chronic M factor of 10 is also assigned, to match the acute M factor, as the classification has been determined based on acute data.
$ Environmental classification is assessed based on the lowest acute and chronic values from ecotoxicity tests. Algae and fish toxicity values are read across from hexachloroplatinic acid. The lowest acute value is a 48-hour EC50 of 0.284 mg diammonium hexachloroplatinate L-1 (0.108 mg Pt L-1) based on the short-term toxicity study on aquatic invertebrates performed with the substance itself. The lowest chronic value is a 21-day NOEC value of 0.007 mg Pt L-1 for Daphnia, based on reproduction, read across from hexachloroplatinic acid. Converting the NOEC value to a concentration of diammonium hexachloroplatinate based on molecular weight gives a NOEC of 0.016 mg diammonium hexachloroplatinate L-1. As a complete chronic dataset (fish, Daphnia and algae) is not available, classification is assessed based on both the acute and chronic data and the worst case classification assigned to the substance. Based on the acute data, an environmental classification of Acute Category 1, Chronic Category 1 is assigned to this substance. As the lowest EC50 value is >0.1 ≤ 1 an acute M factor of 1 is assigned. A chronic M factor of 1 is also assigned, to match the acute M factor, as the classification has been determined based on acute data.
£ Environmental classification is assessed based on the lowest acute and chronic values from ecotoxicity tests. For this substance, all values are read across from hexachloroplatinic acid. For classification purposes, these values have been expressed as concentrations of dipotassium hexachloroplatinate, converted based on molecular weight. The lowest acute value is a 48-hour EC50 of 0.0205 mg Pt L-1for aquatic invertebrates(mobility) and the lowest chronic value is a 21-day NOEC value of 0.007 mg Pt L-1 for Daphnia, based on reproduction. This results in an EC50 of 0.051 mg dipotassium hexachloroplatinate L-1 and a NOEC of 0.017 mg dipotassium hexachloroplatinate L- 1. A full chronic dataset (fish, Daphnia and algae) is not available for this substance, therefore classification has been assessed based on both the acute and chronic data, with the worst case classification assigned. An environmental classification of Acute Category 1, Chronic Category 1 is assigned to this substance, based on acute data. As the lowest EC50 value is >0.01 ? 0.1 an acute M factor of 10 is assigned. A chronic M factor of 10 is also assigned, to match the acute M factor, as the classification has been determined based on acute data
+ Environmental classification is assessed based on the lowest acute and chronic values from ecotoxicity tests performed with the substance itself. The lowest acute value is a 48 -hour EC50 of 0.742 mg test item L-1 (0.481 mg Pt L-1) for aquatic invertebrates(mobility) and the lowest chronic value is a 72-hour NOEC of 0.946 mg test item L-1 (0.613 mg Pt L-1) for algae (yield and growth rate). For this substance, the only chronic data available is an algal NOEC, therefore classification is assessed based on both the acute and chronic data and the worst case classification assigned to the substance. Based on these results, an environmental classification of Acute Category 1, Chronic Category 1 is assigned. As the lowest EC50 value is >0.1 ≤ 1 an acute M factor of 1 is assigned. A chronic M factor of 1 is also assigned, to match the acute M factor, as the classification has been determined based on acute data.
% Environmental classification is assessed based on the lowest acute and chronic values from ecotoxicity tests. A full base set of ecotoxicity data are available for this substance, and both platinum and 2-aminoethanol concentrations were analysed in the studies. For fish and Daphnia, no effects were observed up to the highest test concentration. Classification of this substance is therefore based on the algal results and test item concentrations in the study were determined based on measured platinum concentrations. The lowest acute value is a 48-hour EC50 of 0.682 mg test item L-1 (growth rate) and the lowest chronic value is a 72-hour EC10 of 0.039 mg test item L-1 (growth rate). For this substance, the only chronic data available is an algal EC10, therefore classification is assessed based on both the acute and chronic data and the worst case classification assigned to the substance. Based on these results, an environmental classification of Acute Category 1, Chronic Category 1 is assigned to this substance. As the lowest EC50 value is >0.1 ≤ 1 an acute M factor of 1 is assigned. A chronic M factor of 1 is also assigned, to match the acute M factor, as the classification has been determined based on acute data.
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