Registration Dossier
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EC number: 203-326-3 | CAS number: 105-74-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 – 26 November, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- , April 13, 2004
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- other: ISO 9001
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Remarks on result:
- other: Since the result is derived from references, no temperature or pH are given.
- Details on results:
- Since the result is derived from references, no temperature or pH are given.
- Conclusions:
- The partition coefficient Log Pow of dilauroyl peroxide is > 6.5.
- Executive summary:
The study was conducted to determine the partition coefficient of the substance. The average measured Pow value for dilauroyl peroxide is found to be far beyond the calibration range. Log Pow value of dilauroyl peroxide is > 6.5. Extrapolation of the current values results in roughly estimated Pow of 1E - 12 (Log Pow = 12).
Log Pow of dilauroyl peroxide is > 6.5.
Reference
The average theoretical Log Powvalues are all taken from OECD guideline 117.
Average retention times of reference substances and Laurox
|
Log Pow (theoritical) |
Retention time (minute) |
k |
Log k |
Thiourea |
0 |
2.432 |
0 |
- |
Aniline |
0.9 |
3.922 |
0.613 |
-0.213 |
Anisole (methoxybenzene) |
2.1 |
4.898 |
1.014 |
0.006 |
Benzophenone |
3.2 |
5.087 |
1.092 |
0.038 |
Diphenylether |
4.2 |
6.597 |
1.713 |
0.234 |
Triphenylamine |
5.7 |
8.559 |
2.519 |
0.401 |
DDT |
6.5 |
11.695 |
3.809 |
0.581 |
|
|
|
|
|
Laurox |
|
45.74 |
17.81 |
1.25 |
It can be clearly seen that the test substance Laurox elutes at a retention time of 45.74 minute which is far beyond the retention times of the reference substances and even of the reference DDT with the highest Log Powof 6.5. Therefore it can be stated that theLog Pow value of Laurox is > 6.5.
Description of key information
The partition coefficient Log Pow of dilauroyl peroxide is > 6.5.
For risk assessment purposes the lowest estimated log Kow is used.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 10.3
Additional information
The average measured Pow value for Laurox is found to be far beyond the calibration range.
Log Pow value of Laurox is > 6.5.Extrapolation of the current values results in roughly estimated Pow of 1E - 12 (Log Pow = 12).
Model calculations also show that the Log Pow of Laurox is significantly higher than 6.5.
KOWWIN,Pow value is 10.34.
ACD labs,Pow value is 10.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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