Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 – 26 November, 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
, April 13, 2004
Deviations:
no
GLP compliance:
no
Other quality assurance:
other: ISO 9001
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 6.5
Remarks on result:
other: Since the result is derived from references, no temperature or pH are given.
Details on results:
Since the result is derived from references, no temperature or pH are given.

The average theoretical Log Powvalues are all taken from OECD guideline 117. 

Average retention times of reference substances and Laurox

 

 

Log Pow

(theoritical)

Retention time (minute)

k

Log k

Thiourea

0

2.432

0

 -

Aniline

0.9

3.922

0.613

-0.213

Anisole (methoxybenzene)

2.1

4.898

1.014

0.006

Benzophenone

3.2

5.087

1.092

0.038

Diphenylether

4.2

6.597

1.713

0.234

Triphenylamine

5.7

8.559

2.519

0.401

DDT 

6.5

11.695

3.809

0.581

 

 

 

 

 

Laurox

 

45.74

17.81

1.25

It can be clearly seen that the test substance Laurox elutes at a retention time of 45.74 minute which is far beyond the retention times of the reference substances and even of the reference DDT with the highest Log Powof 6.5. Therefore it can be stated that theLog Pow value of Laurox is > 6.5.

Conclusions:
The partition coefficient Log Pow of dilauroyl peroxide is > 6.5.
Executive summary:

The study was conducted to determine the partition coefficient of the substance. The average measured Pow value for dilauroyl peroxide is found to be far beyond the calibration range. Log Pow value of dilauroyl peroxide is > 6.5. Extrapolation of the current values results in roughly estimated Pow of 1E - 12 (Log Pow = 12).

Log Pow of dilauroyl peroxide is > 6.5.

Description of key information

The partition coefficient Log Pow of  dilauroyl peroxide is > 6.5.

For risk assessment purposes the lowest estimated log Kow is used.

Key value for chemical safety assessment

Log Kow (Log Pow):
10.3

Additional information

The average measured Pow value for Laurox is found to be far beyond the calibration range.

Log Pow value of Laurox is > 6.5.Extrapolation of the current values results in roughly estimated Pow of 1E - 12 (Log Pow = 12).

Model calculations also show that the Log Pow of Laurox is significantly higher than 6.5.

KOWWIN,Pow value is 10.34.

ACD labs,Pow value is 10.6.