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Diss Factsheets
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EC number: 946-911-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 to 30 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health
- Type of method:
- flask method
- Key result
- Water solubility:
- 2.68 g/L
- Temp.:
- 20 °C
- pH:
- >= 3.8 - <= 6.5
- Remarks on result:
- other: sum of four constituents
- Conclusions:
- A water solubility value of 2.68 ± 0.03 g/L (at 20 °C, pH = 3.8-6.5) was determined for the test substance according to OECD 105.
Reference
The test item consists of several constituents, resulting in four peaks under the given HPLC conditions. The evaluation of the water solubility was made based on the sum of the peak areas. The results are given in the following table.
Results of the Water Solubility of the test item.The tabulated values represent rounded results, obtained by calculation using the exact raw data.
Sample No. |
Shaking time at 30 °C |
Test item solution pH |
Determined concentration |
Water Solubility Mean Value |
Overall Mean ± Std. Dev. |
Rel. Std. Dev. |
|
[hours] |
|
[mg/L] |
[mg/L] |
[mg/L] |
[%] |
|
Higher Loading rate |
|||||
72-7 |
72 |
3.79 |
2717 |
2728 |
2694 ± 30 |
1.1 |
72-8 |
72 |
3.78 |
2739 |
|||
48-7 |
48 |
3.74 |
2706 |
2687 |
||
48-8 |
48 |
3.80 |
2668 |
|||
24-7 |
24 |
3.82 |
2667 |
2668 |
||
24-8 |
24 |
3.95 |
2669 |
|||
|
Lower Loading rate |
|||||
72-5 |
72 |
6.52 |
2651 |
2666 |
2667 ± 34 |
1.3 |
72-6 |
72 |
6.28 |
2682 |
|||
48-5 |
48 |
6.66 |
2713 |
2702 |
||
48-6 |
48 |
6.45 |
2690 |
|||
24-5 |
24 |
6.24 |
2643 |
2634 |
||
24-6 |
24 |
6.99 |
2625 |
|||
|
Total Mean of 6 tests |
2681 ± 32 |
1.2 |
At the higher loading rate (about 100 g/L) an overall mean content in water of 2.69 ± 0.03 g/L was obtained at a pH ca. 3.8. At the lower loading rate (about 10 g/L) an overall mean of 2.67 ± 0.03 g/L was obtained at a pH ca. 6.5. Since there is no significant difference between the two loading rates, the water solubility determination based on summing up of the peak areas of the individual constituents is an appropriate procedure for the test compound. The water solubility of the test compound was calculated based on the mean values of the six assays.
The water solubility of the test item based on evaluation of the peak area sum of four constituents was found to be 2.68 ± 0.03 g/L.
Description of key information
Water solubility: 2.68 ± 0.03 g/L at 20 °C, pH = 3.8-6.5 (OECD 105, shake flask method)
Key value for chemical safety assessment
- Water solubility:
- 2.68 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility determination based on evaluation of the peak area sum of four constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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