Registration Dossier
Registration Dossier
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EC number: 203-192-6 | CAS number: 104-29-0
Endpoint summary
Administrative data
Description of key information
LD50 rat oral route = 3000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- Study conducted according to internationally accepted testing guidelines.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An acute oral toxicity test on Chlorphenesin was performed in 1993, before the implementation of the Regulation (EC.1223/2009) and the result of this study was LD50 rat oral route = 3000 mg/kg bw .
According to the Commission Regulation (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006 testing by the dermal route does not need to be conducted if the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation): LD 50 oral route for Chlorphenesin is major than 2000 mg/kg bw and no classification is required for acute oral toxicity.
Testing by inhalation route is not appropriate for Chlorphenesin based on exposure of human via inhalation is unlike.
Justification for classification or non-classification
Chlorphenesin is not classified for acute toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
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