Registration Dossier
Registration Dossier
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EC number: 203-192-6 | CAS number: 104-29-0
Endpoint summary
Administrative data
Description of key information
NOEL Chlorphenesin (repeated oral toxicity rat 28 days) = 10 mg/kg bw/day
NOAEL Chlorphenesin (repeated oral toxicity rat 28 days) = 100 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Study conducted according to internationally accepted testing guidelines.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vivo test to assess the repeated dose toxicity of Chlorphenesin was performed in 1990 before the implementation of the Regulation (EC n.1223/2009). Chlorphensin was tested for repeated oral toxicity during an administration period of 28 days by oral gavage at dosage levels of 1000, 100 and 10 mg/kg bw/day. Some relevant effects that caused the sacrifice on humane grounds of 1 of 32 animals (16 males and 16 females) were recorded at the highest dose 1000 mg/kg bw/day. There is no data in the range 100 and 1000 mg/kg bw/day but no specific target organ was identified at 1000 mg/kg bw/day. The NOAEL Chlorphenesin (repeated oral toxicity rat 28 days) = 100 mg/kg bw /day.
Justification for classification or non-classification
Chlorphenesin is not classified for repeated dose toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
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