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Description of key information

NOEL Chlorphenesin (repeated oral toxicity rat 28 days) = 10 mg/kg bw/day

NOAEL Chlorphenesin (repeated oral toxicity rat 28 days) = 100 mg/kg bw/day

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
100 mg/kg bw/day
Study duration:
subacute
Species:
rat
Quality of whole database:
Study conducted according to internationally accepted testing guidelines.

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In vivo test to assess the repeated dose toxicity of Chlorphenesin was performed in 1990 before the implementation of the Regulation (EC n.1223/2009). Chlorphensin was tested for repeated oral toxicity during an administration period of 28 days by oral gavage at dosage levels of 1000, 100 and 10 mg/kg bw/day. Some relevant effects that caused the sacrifice on humane grounds of 1 of 32 animals (16 males and 16 females) were recorded at the highest dose 1000 mg/kg bw/day. There is no data in the range 100 and 1000 mg/kg bw/day but no specific target organ was identified at 1000 mg/kg bw/day. The NOAEL Chlorphenesin (repeated oral toxicity rat 28 days) = 100 mg/kg bw /day.

Justification for classification or non-classification

Chlorphenesin is not classified for repeated dose toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.

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