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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
15 mg/kg bw/day

Carcinogenicity: via dermal route

Endpoint conclusion
Dose descriptor:
1 mg/kg bw/day

Justification for classification or non-classification

Additional information

A number of chronic toxicity/carcinogenicity studies have been conducted. In the most recently conducted studies, the NOAEL was 15 and 100 mg/kg/day in male and female rats, respectively, following two years oral administration of BADGE. Decreased body weight and an enlarged cecum were observed in male rats at 15 mg/kg/day in the oral study. In the dermal chronic toxicity/carcinogenicity studies, male mice and female rats were used. The systemic NOEL was 1 mg/kg/day in female rats and 100 mg/kg/day in male mice. Histopathologic changes were observed in the liver of female rats administered 10 and 100 mg/kg/day. These changes were attributed to ingestion since the test material was not occluded. In male mice the NOEL at the application site was 0.1 mg/kg/day. Epidermal hyperplasia, chronic dermal inflammation and epidermal crusts were observed histopathologically at dosages of 10 and 100 mg/kg/application in male mice.

Carcinogenicity: via oral route (target organ): digestive: cecum

Carcinogenicity: via dermal route (target organ): digestive: liver