Oxydiethylene bis(chloroformate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study (OECD TG 403) with acceptable restrictions. Restriction: no analytical monitoring of the atmosphere concentration. Observation period not reported.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

: no analytical monitoring of the atmosphere concentration.

GLP compliance:

no

Test type:

other: Inhalation Risk Test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Oxydiethylene bis(chloroformate)

EC Number:

203-430-9

EC Name:

Oxydiethylene bis(chloroformate)

Cas Number:

106-75-2

Molecular formula:

C6H8Cl2O5

IUPAC Name:

oxydiethane-2,1-diyl dichlorocarbonate

Details on test material:

- Name of test material (as cited in study report): Diglycoldichlorkolensäureester
- Physical state: liquid
- Analytical purity: no data
- Other: pH 1; Melting point +4 °C; Boiling point 199 °C

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: mean of 3 males and 3 females 170 g (experiment 1) 3 males and 3 females 156 g (experiment 2 same conditions)

ENVIRONMENTAL CONDITIONS
no data

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

other: inhalation chamber

Vehicle:

other: air

Details on inhalation exposure:

Animals were exposed to a saturated atmosphere in an inhalation chamber. Atmosphere generation: dynamic. Air was conducted through a 5-cm
layer of TS in a fritted wash bottle. Nominal concentration was 0.0875 mg/L

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

saturated atmosphere

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: mean body weight prior to exposure and at termination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

none

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.087 mg/L air (nominal)

Exp. duration:

8 h

Mortality:

no deaths

Clinical signs:

other: Initially attempts to escape; slight irritation of the mucosa.

Body weight:

meaan body weight development was positive.
day 0: mean of 3 males and 3 females 170 g (experiment 1); 3 males and 3 females 156 g (experiment 2 same conditions)
day 7: mean of 3 males and 3 females 187 g (experiment 1) ; 3 males and 3 females 170 g (experiment 2 same conditions)

Gross pathology:

Necropsy findings: 2 cases of chronic bronchitis, 1 case of bronchiectasia.

Any other information on results incl. tables

Mortality:

               ---------------------------

                  Exposure         Animals

                  period        dead/exposed

                  ---------------------------

                    8 h            0/12

                   ---------------------------

Signs of toxicity: Initially attempts to escape; slight irritation of the mucosa.

Necropsy findings:

2 cases of chronic bronchitis, 1 case of bronchiectasia.

Applicant's summary and conclusion

Conclusions:

According to OECD TG 403 there is no likely inhalation hazard under normal conditions of exposure.