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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 - 21 December 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Ministery of Health, Italy
Type of method:
effusion method: Knudsen cell

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylimidazole
EC Number:
211-581-7
EC Name:
2-phenylimidazole
Cas Number:
670-96-2
Molecular formula:
C9H8N2
IUPAC Name:
2-phenylimidazole
Test material form:
solid: flakes

Results and discussion

Vapour pressure
Key result
Temp.:
20 °C
Vapour pressure:
0.009 Pa

Any other information on results incl. tables

Results of the analysis

The result of the thermogravimetric analysis for test item and the vapour pressure at 20 °C are given in the following table.

T

[°C]

Δm

[mg]

Δt

[min]

T

[K]

1/T

[1/K]

Δm/Δt

[kg/s]

Vapour pressure

[Pa]

log p

33.5

0.0366

80

306.65

3.26E-03

7.63E-12

6.08E-02

-1.2160

39.6

0.0705

80

312.75

3.20E-03

1.47E-11

1.18E-01

-0.9270

46.1

0.1085

80

319.35

3.13E-03

2.26E-11

1.84E-01

-0.7353

52.9

0.1592

80

326.05

3.07E-03

3.32E-11

2.73E-01

-0.5642

60.0

0.2544

80

333.15

3.00E-03

5.30E-11

4.41E-01

-0.3560

67.4

0.4844

80

340.35

2.94E-03

1.01E-10

8.48E-01

-0.0715

75.1

1.0051

80

348.25

2.78E-03

2.09E-10

1.78E+00

0.2503

81.9

2.0799

80

355.05

2.82E-03

4.33E-10

3.72E+00

0.5704

39.5

0.0281

80

312.65

3.20E-03

5.85E-12

4.71E-02

-1.3266

45.8

0.0572

80

318.95

3.14E-03

1.19E-11

9.69E-02

-1.0135

52.3

0.1181

80

325.45

3.07E-03

2.46E-11

2.02E-01

-0.6943

 59.3  0.2088  80  332.45  3.01E-03  4.35E-11  3.61E-01  -0.4422
66.5   0.4532  80  339.65  2.94E-03  9.44E-11  7.93E-01  -0.1010
 73 .6  0.9832  80  346.75  2.88E-03  2.05E-10  1.74E+00  0.2398
 81.3  2.1148  80  354.45  2.82E-03  4.41E-10  3.78 E+00  0.5772

 

Since the analysis was conducted under high vacuum conditions, the heat could be transferred only by radiation, this caused a consistent difference between the furnace temperature and the sample one and a considerable time for the system to reach equilibrium.

The temperatures reported (registered by the thermocouple under the Knudsen cell) are hence different from the one set and the mass loss has been measured only in 80 minutes time interval within each isotherm, after the system had reached equilibrium.

 

Determination of the vapour pressure curve

y = mx + q

Parameter m

(slope)

Parameter q

(intercept)

Parameter R²

(correlation)

-4230

12

0.96276

 

Extrapolation of the vapour pressure at 20 °C

Extrapolation at 20°C

1/Temperature

[1/K]

log p

Vapour pressure

[Pa]

0.00341

-2.0289

9.36 x 10-3

 

Applicant's summary and conclusion