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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP. The described method is not equivalent to OECD guideline.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1976

Materials and methods

Principles of method if other than guideline:
-Principle of test: Irritation was evaluated as a part of an acute dermal LD50 study conducted on 10 rabbits. Irritation was assess after a single 24 h occluded dermal application of neat (5000 mg/kg) fenchyl acetate.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
EC Number:
237-588-5
EC Name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
Cas Number:
13851-11-1
Molecular formula:
C12H20O2
IUPAC Name:
1,3,3-trimethylbicyclo[2.2.1]hept-2-yl acetate

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
24 h
Number of animals:
10

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
probability of moderate irritation

Any other information on results incl. tables

A single 24 h occluded dermal application of neat (5 g/kg) test material produced moderate erythema (10/10) and slight (1/10) to moderate (7/10) edema, observed after patch removal.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance was moderately irritating to the skin of rabbits.
Executive summary:

Irritation was evaluated as a part of an acute dermal LD50 study conducted on 10 rabbits. A single 24 h occluded dermal application of neat (5 g/kg) test material produced moderate erythema (10/10) and slight (1/10) to moderate (7/10) edema, observed after patch removal. The substance was moderately irritating to the skin.

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