Registration Dossier
Registration Dossier
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EC number: 947-369-2 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrilotrimethylenetris(phosphonic acid)
- EC Number:
- 229-146-5
- EC Name:
- Nitrilotrimethylenetris(phosphonic acid)
- Cas Number:
- 6419-19-8
- Molecular formula:
- C3H12NO9P3
- IUPAC Name:
- [nitrilotris(methylene)]tris(phosphonic acid)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- treatment was carried out once
Doses / concentrationsopen allclose all
- Dose / conc.:
- 10 mg/kg bw/day
- Dose / conc.:
- 50 mg/kg bw/day
- No. of animals per sex per dose / concentration:
- 4M
- Control animals:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Intestinal absorption was found to be minimal based on the measurements of radioactivity from stomach/bowel and urine. At the 10mg/kg dose, 1.85% of the administered radioactivity was intestinally absorbed, and at the 50 mg/kg 2.01%.
- Details on distribution in tissues:
- The carcass and bones suggest that the test material may be bone-specific.
- Details on excretion:
- After oral administration of the test material, the largest amount of radioactivity was found in the faeces. The percentage excreted in the faeces is either not intestinally absorbed or intestinally absorbed and excreted as bile in faeces. In order to further investigate whether excretion is via bile a intravenous or subcutaneous application of test material is required.
Applicant's summary and conclusion
- Conclusions:
- The results suggest bone-specific bio-accumulation.
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