Hydrocarbons, C12-C14, isoalkanes, cyclics, <2%... - Registration Dossier
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EC number: 701-198-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This robust summary has a reliability rating of 1 because the study followed a standard guideline, followed GLP guidelines, and was conducted without deviations that would invalidate the study.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Developed by Huls AG (Dr. Schoberl)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Effects were measured by comparing oxygen consumption by the bacterium, Pseudomonas putida, over 5 hours incubation in test systems that contained varying amounts of test substance in comparison to test systems that contained no test substance (control).
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Test systems were 100 ml bottles containing medium. All test systems were stirred through the exposure period. Four innoculated bottles were established per test substance concentration. Two of these bottles at each concentration also contained HgCl2 and acted as autooxidation controls. Four innoculated bottles without test substance and with HgCl2 also acted as controls. Five innoculated bottles without test substance and HgCl2 also acted as controls. All test systems were stirred during the test.
- Test organisms (species):
- Pseudomonas putida
- Details on inoculum:
- The original culture was obtained from the Institut fur Wasser-, Boden- und lufthygiene des BGA (Berlin, Germany).
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 5 h
- Post exposure observation period:
- None
- Test temperature:
- 25.3
- Nominal and measured concentrations:
- Nominal loading levels were 100, 500, 1000, and 2000 ul/L.
- Key result
- Duration:
- 5 h
- Dose descriptor:
- other: EL0
- Effect conc.:
- 2 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 5 h
- Dose descriptor:
- other: EL10
- Effect conc.:
- > 2 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 5 h
- Dose descriptor:
- other: EL50
- Effect conc.:
- > 2 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 5 h
- Dose descriptor:
- other: EL100
- Effect conc.:
- > 2 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Reported statistics and error estimates:
- None were needed as no effect was measured.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance at the highest loading rate, 2 ml/L, did not inhibit the respiration rate of Pseudomonas putida over an exposure period of 5 hours.
- Executive summary:
The test substance at the highest loading rate, 2 ml/L, did not inhibit the respiration rate of Pseudomonas putida over an exposure period of 5 hours.
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- Tetrahymena pyriformis
- Test type:
- other: QSAR modeled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: EL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrocarbons, 12-C13, isoalkanes, cyclics, <2% aromatics, estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is >1000 mg/L based on growth inhibition.
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C12-C13, isoalkanes, cyclics, <2% aromatics, estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is >1000 mg/L based on growth inhibition.
Referenceopen allclose all
Description of key information
Isododecane at the highest loading rate, 2 ml/L, did not inhibit the respiration rate of Pseudomonas putida over an exposure period of 5 hours. These data are used as read-across data to hydrocarbons, C12-C13,
isoalkanes, cyclics, <2% aromatics.
The hydrocarbons, C12-C13, isoalkanes, <2% aromatics, estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is >1000 mg/L based on growth inhibition.
Key value for chemical safety assessment
Additional information
Isododecane at the highest loading rate, 2 ml/L, did not inhibit the respiration rate of Pseudomonas putida over an exposure period of 5 hours. These data are used as read-across data to hydrocarbons, C12-C13, isoalkanes, cyclics, <2% aromatics.
The hydrocarbons, C12-C13, isoalkanes, cyclics, <2% aromatics, estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is >1000 mg/L based on growth inhibition.
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