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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
Note that this is old data from testing done in 1989.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonafluoro(trifluoromethyl)cyclopentane
EC Number:
217-298-5
EC Name:
Nonafluoro(trifluoromethyl)cyclopentane
Cas Number:
1805-22-7
Molecular formula:
C6F12
IUPAC Name:
1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane
Test material form:
other: liquid
Details on test material:
Room temperature

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
ca. 0.3
Max. score:
1
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
ca. 0
Max. score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
ca. 0.3
Max. score:
1
Irritation parameter:
erythema score
Basis:
mean
Time point:
7 d
Score:
ca. 0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Score:
ca. 0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
7 d
Score:
ca. 0
Max. score:
0
Irritant / corrosive response data:
"The test material, PERFLUOROMETHYL CYCLOHEXANE, was found to be a mild irritant to rabbit skin.
The test material was regarded as non-irritant according to EEC labelling regulations and no symbol and risk phrase are required."

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The substance is considered no to be corrisive.
Executive summary:

The substance is considered no to be corrisive.