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EC number: 212-667-7 | CAS number: 841-77-0
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient documentation for an assessment of reliability.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-benzhydrylpiperazine
- EC Number:
- 212-667-7
- EC Name:
- 1-benzhydrylpiperazine
- Cas Number:
- 841-77-0
- Molecular formula:
- C17H20N2
- IUPAC Name:
- 1-(DIPHENYLMETHYL)PIPERAZINE
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-130806-AAA (T000750)
- Physical state: solid (powder)
- Appearance: white to slight beige powder
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- methanol
- Solubility:
- > 50 other: g/100 mL solution
- Medium:
- ethanol
- Solubility:
- > 50 other: g/100 mL solution
- Medium:
- isopropanol
- Solubility:
- 21.5 other: g/100 mL solution
- Medium:
- other: dichloromethane
- Solubility:
- > 50 other: g/100 mL solution
- Medium:
- acetone
- Solubility:
- 30.5 other: g/100 mL solution
- Medium:
- ethyl acetate
- Solubility:
- 24 other: g/100 mL solution
- Medium:
- toluene
- Solubility:
- 32.2 other: g/100 mL solution
- Medium:
- other: 4-methyl-2-pentanone
- Solubility:
- 17 other: g/100 mL solution
- Medium:
- other: 2-butanone
- Solubility:
- 28.7 other: g/100 mL solution
- Medium:
- other: diethylether
- Solubility:
- 15.2 other: g/100 mL solution
- Details on results:
- no data
Any other information on results incl. tables
Table 1 Solubility of the T000750 at room temperature
| Solvent | Concentration in g/100 mL solution |
| tetrahydrofuran | 48.7 |
| N,N-dimethylformamide | 34.6 |
| dimethylsulfoxide | 17 |
| hexane | 2.44 |
| N,N-dimethylacetamide | 34.9 |
| diisopropylether | 4.8 |
Applicant's summary and conclusion
- Conclusions:
- The solubility of T000750 was determined in different organic solvents and ranged from 4.8 g/100 mL in diisopropylether to 48.7 g/100 mL in THF.
- Executive summary:
Not applicable
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