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EC number: 275-062-7 | CAS number: 70955-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- EPA/600/4-90/027 and ASTM's Methods E729, 1997, Volume 11.05
- Qualifier:
- according to guideline
- Guideline:
- other: EPA/600/4-90/027 and ASTM's Methods E729, 1997, Volume 11.05
- Deviations:
- not specified
- Principles of method if other than guideline:
- see EPA/600/4-90/027, Methods for Measuring the Acute Toxicitv of Effluents and Receiving Waters to Freshwater Organisms, and by ASTM's Methods E729, 1997, Volume 11.05, Annual Book of ASTM Standards. Standard Guide for Conducting Acute Toxicitv Tests on Test Materials with Fishes, Macroinvertebrates, and Amphibians.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Details on test solutions:
- The stock solutions used for the test solutions were prepared by diluting a known weight (grams) of the test material to a known volume. methanol as the solvent carrier was used.
Fourth Edition, by GLEC's (Great Lakes Environmental Center) Standard Operating Procedure for Stock Solution Preparation for Polymers (Detergents and Chemical Additives). - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnows
- Strain: Pimephales promelas,
- Source: no data available
- Age at study initiation (mean and range, SD): less than 24 hours old
- Length at study initiation (length definition, mean, range and SD): no data available
- Weight at study initiation (mean and range, SD): no data available
- Method of breeding: no data available
- Maintenance of the brood fish: no data available
ACCLIMATION
- Acclimation period: no data available
- Acclimation conditions (same as test or not): no data available
- Type and amount of food during acclimation: no data available
- Feeding frequency during acclimation: no data available
- Health during acclimation (any mortality observed): no data available
QUARANTINE (wild caught)
- Duration: no data available
- Health/mortality: no data available
FEEDING DURING TEST
- Food type: no data available
- Amount: no data available
- Frequency: no data available - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Hardness:
- no data available
- Test temperature:
- 25 +/-1°C
- pH:
- no data available
- Dissolved oxygen:
- no data available
- Salinity:
- no data available
- Conductivity:
- no data available
- Nominal and measured concentrations:
- Nominal concentrations: 0.34; 0.68; 1.36; 2.73 and 5.45 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable):closed
- Material, size, headspace, fill volume: covered glass beakers containing at least 250 mL of the test solution or control
- Aeration: yes, The test solutions were aerated with a glass gas dispersion tube or a glass pipette at a rate that did not exceed 100 bubbles per minute
- Renewal rate of test solution (frequency/flow rate): 24 hour-renewal. . Toxicant/effluent renewal was performed daily; within two hours of the test start time.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): no data available
- Biomass loading rate: no data available
TEST MEDIUM / WATER PARAMETERS
No data available
OTHER TEST CONDITIONS
- Adjustment of pH: Sodium hydroxide and hydrochloric or sulfuric acids were used to adjust the pH of the test solution, if needed.
- Photoperiod: A 16-hour light: 8 hour dark photoperiod
- Light intensity: no data available
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Survival was checked daily and the dead fish were removed. Fish weight was measured at the end of the test.
LC50, NOEC and LOEC values were calculated based on adult survival, growth (weight)
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 0.5
- Range finding study
- Test concentrations: A range-finding toxicity test was conducted initially on each fragrance chemical at one to three times the estimated water solubility to determine the test concentrations for the definitive chronic toxicity tests.
- Results used to determine the conditions for the definitive study: Based on the results of the range-finding tests, we initiated the definitive chronic toxicity tests with fathead minnows using three times the estimated water solubility as the highest test concentration and a dilution factor of 0.5 to produce test concentrations. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Key result
- Duration:
- 7 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No other data
- Results with reference substance (positive control):
- no data available
- Reported statistics and error estimates:
- no data available
- Validity criteria fulfilled:
- yes
- Remarks:
- Survival and growth in the controls was determined; greater than 80 percent survival and average weight of greater than or equal to 0.250 mg/fish
- Conclusions:
- With a LC50-7days: 1.36 mg/L, isobornylcyclohexanol is toxic for fish.
- Executive summary:
A static renewal fathead minnow (Pimephales promelas) chronic toxicity test (7-days) was performed with Iso bornyl cyclo hexanol according to EPA/600/4-90/027 and ASTM's Methods E729, 1997, Volume 11.05.
Results:
- LC50: 1.36 mg/L
- NOEC: 0.34 mg/L (based on growth)
- LOEC: 1.36 mg/L (based on survival)
With a LC50-7days: 1.36 mg/L, isobornylcyclohexanol is toxic for fish.
Reference
Description of key information
The test item, isobornylcyclohexanol, was considered toxic to Pimephales promelas.
The 7-d LC50 of isobornylcyclohexanol to Pimephales promelas was determined to be 1.36 mg/L based on the mobility; revealing it is toxic for the fish.
Key value for chemical safety assessment
Additional information
A study, scored as Klimisch 2 and flagged as a key study, is available on isobornylcyclohexanol, giving a 7-d-LC50 : 1.36 mg/L and revealing that isobornylcyclohexanol is toxic to fish (S.C. Johnson, 2005).
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