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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 Oct - 09 Oct 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
adopted in 2014
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Storage conditions: ambient temperature (10 – 30 °C)
Water solubility:
ca. 0.88 g/L
Temp.:
20 °C
pH:
ca. 3.2

Results
Table 1 – Preliminary test results

Test item amount [mg]

Added vol. of distilled water [mL]

Total volume [mL]

Appearance of mixture

67.5

0.1

0.1

undissolved

0.4

0.5

0.5

1.0

1.0

2.0

8.0

10.0

 

Water solubility was found to be > 10 mg/L. Therefore, the flask method was used to determine water solubility of the test item.

Flask Method
After equilibration, precipitate was seen in the flasks with the exception of the blank. Water solubility was calculated from measured and unrounded concentration values and not from rounded values given in Table 2.

Table 2 – Test item water solubility

Experiment

24 h experiment

48 h experiment

72 h experiment

Blank experiment (72 h)

Test item amount [g]

1.69

1.70

1.70

--

Demineralized water amount [mL]

50

Stirring time at 30 °C [h]

24

48

72

72

pH at 23 °C

3.2

6.0

Aliquot of the flasks [mL]

0.1

Dilution to volume [mL]

1

Dilution factor

10

Measured concentration [mg/L]

88.32
88.52

87.45
87.64

88.23
88.15

--
--

Mean concentration [mg/L]

88.42

87.55

88.19

--

Water solubility [g/L]

0.884

0.876

0.882

--

 

The water solubility of the test item at 20 °C was determined to be cs= 0.88 g/L (±0.005 g/L).

 

Description of key information

0.88 g/L (± 0.005 g/L) at 20 °C and pH 3.2(OECD 105, Flask method)

Key value for chemical safety assessment

Water solubility:
0.88 g/L
at the temperature of:
20 °C

Additional information

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