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Imwitor 375 is an insoluble UVCB liquid with a low vapour pressure. There is no toxicokinetic data on Imwitor 375 itself, but it is composed of glycerides and glyceride citrate esters with a variety of fatty acid chain lengths and degrees of saturation/unsaturation. Glycerides are found naturally in foodstuff consumed by humans and animals and known to be absorbed following ingestion. However, fats are not absorbed by the skin because they are insoluble in water and therefore are unable to partition from the stratum corneum into the epidermis. There is no data available for the distribution of the UVCB in the body, however it is likely that the breakdown products would be distributed widely given that they contribute to the metabolic/physiological pathways involved in energy production, e.g. Kreb’s cycle. Glyceride citrate esters are likely to be broken down in the gastrointestinal tract into citric acid/citrate and a partial glyceride. The latter would then undergo enzymatic hydrolysis to release fatty acids and glycerol. Bioaccumulation of fatty acids takes place, if their intake exceeds the caloric requirements of the organism. Glycerol can be re-esterified to form endogenous triglycerides, metabolised and/or excreted in the urine. Glycerides would be excreted as carbon dioxide and water following oxidative physiologic metabolism. Any glycerides that are not hydrolysed in the gastrointestinal tract are likely to be excreted in the faeces.

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