4-aminobenzonitrile

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

other: Incident report

Adequacy of study:

supporting study

Study period:

2011

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data from incident report according to HAZOP, no effect concentration available

Cross-reference

Reason / purpose for cross-reference:

exposure-related information

Reference

Name:

T002680

Implementation:

EU

Type of classification:

self-classification

Related composition:

T002680

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Hazard category:

Acute Tox. 4

Hazard statement:

H302: Harmful if swallowed.

Hazard category:

Acute Tox. 3

Hazard statement:

H311: Toxic in contact with skin.

Hazard category:

Acute Tox. 3

Hazard statement:

H331: Toxic if inhaled.

Reason for no classification:

data conclusive but not sufficient for classification

Hazard category:

Eye Irrit. 2

Hazard statement:

H319: Causes serious eye irritation.

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Hazard category:

Muta. 2

Hazard statement:

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Hazard category:

Aquatic Chronic 3

Hazard statement:

H412: Harmful to aquatic life with long lasting effects.

Reason for no classification:

data lacking

Signal word:

Warning

Code:

GHS07: exclamation mark

Code:

GHS06: skull and crossbones

Code:

GHS08: health hazard

Hazard statement:

H302: Harmful if swallowed.

Hazard statement:

H311: Toxic in contact with skin.

Hazard statement:

H331: Toxic if inhaled.

Hazard statement:

H319: Causes serious eye irritation.

Hazard statement:

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Hazard statement:

H412: Harmful to aquatic life with long lasting effects.

Precautionary statement:

P284: [In case of inadequate ventilation] wear respiratory protection.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Expert judgement in allignment with HAZOP

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-aminobenzonitrile

EC Number:

212-850-1

EC Name:

4-aminobenzonitrile

Cas Number:

873-74-5

Molecular formula:

C7H6N2

IUPAC Name:

4-aminobenzonitrile

Results and discussion

Any other information on results incl. tables

At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.

The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact (see justification statement attached to this study summary).

After the incidents, required PPE was improved leading to safe conditions.

Applicant's summary and conclusion

Conclusions:

At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.
The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact.
After the incidents, required PPE was improved leading to safe conditions.

Executive summary:

At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.

The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact.

After the incidents, required PPE was improved leading to safe conditions.