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EC number: 239-825-8 | CAS number: 15733-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 Oct 1996 to 28 Nov 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-B (Determination of the "Ready" Biodegradability - Modified OECD Screening Test)
- Deviations:
- yes
- Remarks:
- intial test substance concentration lower than proposed in guideline
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Remarks:
- Aquatic mixed population of microorganisms (activated sludge)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Effluent of a laboratory living sludge plant that is operated with wastewater from the southern Wupper Association.
- Date of sampling: 31.10.1996
- Pretreatment: None
- Concentration of sludge: 0.5 mL/L
- Water filtered: yes
- Type and size of filter used, if any: Coarse filter paper - Duration of test (contact time):
- 28 d
- Initial conc.:
- 9.03 mg/L
- Based on:
- DOC
- Initial conc.:
- 4.1 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 ± 2 °C
- Continuous darkness: yes
SAMPLING
- Sampling frequency: after 0, 7, 14, 21, 27 and 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes - Reference substance:
- aniline
- Parameter:
- % degradation (DOC removal)
- Value:
- 83
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- % Degradation at an initial concentration of 9.03 mg DOC/L
- Parameter:
- % degradation (DOC removal)
- Value:
- 79
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- % Degradation at an initial concentration of 4.1 mg DOC/L
- Details on results:
- Please refer to "any other information on results incl. tables".
- Results with reference substance:
- 92 % degradation after 14 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- After 28 days a degradation of 83 % was observed at concentrations of 9.03 and 4.10 mg/L DOC, respectively. Therefore the test item can be considered as ready biodegradable.
- Executive summary:
The ready biodegradability of sodium p-chloro-m-cresol was investigated according to EU C. 4-B method (Modified OECD Screening Test (Müller 1996)). The effluent of a laboratory scale was treated with the test item at a concentration of 9 mg/L DOC and incubated in the dark for 28 days. As test parameter the removal of dissolved organic carbon was measured. After 28 days a degradation of 79 - 83 % was observed. Therefore, the test item can be considered as ready biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 23 Aug 1995 - 18 Oct 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Remarks:
- Aquatic mixed population of microorganisms (activated sludge)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Effluent of a laboratory living sludge plant that is operated with wastewater from the southern Wupper Association.
- Date of sampling: 18.08.1995
- Pretreatment: 5 days aeration
- Concentration of sludge: 5 mL/L
- Water filtered: yes
- Type and size of filter used, if any: Coarse filter paper - Duration of test (contact time):
- 56 d
- Initial conc.:
- 5.13 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 20 - 21 °C
- Continuous darkness: yes
SAMPLING
- Sampling frequency: after 0, 7, 14, 21, 28, 35, 42, 49 and 56 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes, 5.13 mg/L test item with 2.0 mg/L reference item - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 18
- Sampling time:
- 56 d
- Details on results:
- For results on the test substance section "Any other information on results incl. tables".
A pre-test was conducted (closed bottle) a degradation of 42% was reached after 28 days. - Results with reference substance:
- 62 % degradation after 14 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under test conditions 18 % biodegradation was observed after 56 days.
- Executive summary:
The ready biodegradability of sodium p-chloro-m-cresol was investigated according to EU C. 4-E method (closed bottle test (Caspers & Müller 1996). The effluent of a laboratory scale was treated with the test item at a concentration of 5.13 mg/L and incubated in the dark for 56 days. As test parameter the oxygen consumption was measured. After 56 days a degradation of 18 % was observed, therefore the test item cannot be considered as ready biodegradable. The results of the pre-test showed a degradation of 42 %.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 13 Jun 1996 - 11 Jul 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-B (Determination of the "Ready" Biodegradability - Modified OECD Screening Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent of a laboratory scale
- Details on inoculum:
- - Source of sewage: south of Wupperverband
- Concentration of sludge: 0.5 mL/L
- Water filtered: yes - Duration of test (contact time):
- 28 d
- Initial conc.:
- 18 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 ± 2 °C
- Continuous darkness: yes
SAMPLING
- Sampling frequency: after 0, 7, 14, 21, 27 and 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes - Reference substance:
- aniline
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Please refer to "any other information on results incl. tables".
- Results with reference substance:
- 96 % degradation after 14 days.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under test conditions no biodegradation was observed (0 % after 28 d).
- Executive summary:
The ready biodegradability of sodium p-chloro-m-cresol was also investigated according to EU C. 4 –B method (Modified OECD Screening Test (Caspers & Müller 1996)). The effluent of laboratory scale was treated with the test item at a concentration of 18 mg/L and incubated in the dark for 28 days. As test parameter the removal of dissolved organic carbon was measured. After 28 days no degradation was observed, therefore the test item cannot be considered as ready biodegradable.
Referenceopen allclose all
Table 1: DOC values of test item
9.03 mg/L DOC |
DOC |
|
||||||
Vessel no. |
||||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
||
13 |
a1 |
9.70 |
9.80 |
7.90 |
4.40 |
2.80 |
3.30 |
|
a2 |
10.10 |
9.60 |
6.70 |
4.40 |
2.70 |
3.50 |
|
|
a, mean value |
9.90 |
9.70 |
7.30 |
4.40 |
2.75 |
3.40 |
|
|
14 |
b1 |
9.10 |
10.50 |
5.80 |
2.40 |
3.80 |
1.90 |
|
b2 |
10.20 |
10.90 |
5.90 |
2.20 |
3.30 |
2.40 |
|
|
b, mean value |
9.65 |
10.70 |
5.85 |
2.30 |
3.55 |
2.15 |
|
|
4.10 mg/L DOC |
DOC |
|
||||||
Vessel no. |
||||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
||
15 |
a1 |
5.20 |
4.50 |
1.80 |
1.90 |
2.60 |
2.00 |
|
a2 |
4.40 |
4.60 |
1.80 |
1.80 |
2.90 |
2.20 |
|
|
a, mean value |
4.80 |
4.55 |
1.80 |
1.85 |
2.75 |
2.10 |
|
|
16 |
b1 |
5.00 |
5.00 |
1.20 |
0.90 |
2.20 |
2.60 |
|
b2 |
4.80 |
5.60 |
1.30 |
1.30 |
1.70 |
1.80 |
|
|
b, mean value |
4.90 |
5.30 |
1.25 |
1.10 |
1.95 |
2.20 |
|
|
2.20 mg/L DOC |
DOC |
|
||||||
Vessel no. |
||||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
||
17 |
a1 |
3.20 |
3.50 |
0.40 |
1.00 |
1.80 |
0.80 |
|
a2 |
2.60 |
3.20 |
1.20 |
1.00 |
1.80 |
0.60 |
|
|
a, mean value |
2.90 |
3.35 |
0.80 |
1.00 |
1.80 |
0.70 |
|
|
18 |
b1 |
3.20 |
3.30 |
1.20 |
2.30 |
1.70 |
1.30 |
|
b2 |
2.80 |
4.00 |
2.20 |
3.10 |
1.00 |
1.20 |
|
|
b, mean value |
3.00 |
3.65 |
1.70 |
2.70 |
1.35 |
1.25 |
|
|
1.10 mg/L DOC |
DOC |
|
||||||
Vessel no. |
||||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
||
19 |
a1 |
2.20 |
2.20 |
1.70 |
1.30 |
1.20 |
1.20 |
|
a2 |
1.40 |
1.90 |
2.00 |
1.40 |
1.90 |
1.10 |
|
|
a, mean value |
1.80 |
2.05 |
1.85 |
1.35 |
1.55 |
1.15 |
|
|
20 |
b1 |
2.30 |
2.00 |
2.30 |
1.50 |
1.80 |
1.60 |
|
b2 |
1.50 |
1.90 |
1.10 |
1.40 |
1.50 |
1.80 |
|
|
b, mean value |
1.90 |
1.95 |
1.70 |
1.45 |
1.65 |
1.70 |
|
Table 2: Degradation of test item (for the test concentrations 2.2 mg/L and 1.1 mg/L degradation clould not be determined as DOC values were close to the limit of detection)
9.03 mg/ DOC |
% degradation |
|
|||||
Vessel no. |
|||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
|
13 |
0 |
2 |
23 |
60 |
84 |
77 |
|
14 |
0 |
0 |
37 |
82 |
74 |
90 |
|
mean value |
0 |
1 |
30 |
71 |
79 |
83 |
|
4.10 mg/ DOC |
% degradation |
|
|||||
Vessel no. |
|||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
|
15 |
0 |
6 |
62 |
72 |
63 |
80 |
|
16 |
0 |
0 |
77 |
90 |
83 |
78 |
|
mean value |
0 |
3 |
69 |
81 |
73 |
79 |
|
Table 1: O2 concentration of test item (mg O2/L after x days)
no flasks |
0 d |
no flasks |
7 d |
no flasks |
14 d |
no flasks |
21 d |
no flasks |
28 d |
37 |
7.87 |
39 |
7.89 |
41 |
7.95 |
43 |
7.33 |
45 |
7.46 |
38 |
7.82 |
40 |
7.88 |
42 |
7.84 |
44 |
7.37 |
46 |
7.47 |
Mean value |
7.85 |
|
7.89 |
|
7.90 |
|
7.35 |
|
7.47 |
no flasks |
0 d |
no flasks |
35 d |
no flasks |
42 d |
no flasks |
49 d |
no flasks |
56 d |
37 |
7.87 |
47 |
7.52 |
49 |
7.24 |
51 |
7.37 |
53 |
6.48 |
38 |
7.82 |
48 |
7.24 |
50 |
6.76 |
52 |
6.28 |
54 |
6.46 |
Mean value |
7.85 |
|
7.38 |
|
7.00 |
|
6.83 |
|
6.47 |
Table 2: O2 consumption: % degradation
Test item conc.:5.13 mg/L (ThOD: 1556 mg/L) |
O2 consumption |
|||||||
7 d |
14 d |
21 d |
28 d |
35 d |
42 d |
49 d |
56 d |
|
No 1: (mt0 - mtx) – (mb0 - mbx) |
0.00 |
0.00 |
0.16 |
0.08 |
0.17 |
0.51 |
0.25 |
1.47 |
No 2: (mt0 - mtx) – (mb0 - mbx) |
0.00 |
0.00 |
0.07 |
0.02 |
0.40 |
0.94 |
1.29 |
1.44 |
D1: % degradation |
0 |
0 |
2 |
1 |
2 |
6 |
3 |
18 |
D2: % degradation |
0 |
0 |
1 |
0 |
5 |
12 |
16 |
18 |
D: mean value |
0 |
0 |
2 |
1 |
4 |
9 |
10 |
18 |
Table 3: Results of pre-test
|
7 d |
14 d |
21 d |
28 d |
% degradation |
0 |
1 |
0 |
42 |
Table 1: DOC values of test item
Vessel no. |
DOC |
||||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
||
5 |
a1 |
20.4 |
18.6 |
18.9 |
19.2 |
20.8 |
20.4 |
a2 |
19.2 |
18.9 |
18.3 |
18.1 |
18.9 |
18.9 |
|
a, mean value |
19.8 |
18.8 |
18.6 |
18.7 |
19.9 |
19.7 |
|
6 |
b1 |
21.4 |
19.1 |
18.8 |
18.8 |
20.6 |
20.5 |
b2 |
20.6 |
18.6 |
18.3 |
18.1 |
20.8 |
20.0 |
|
b, mean value |
21.0 |
18.9 |
18.6 |
18.5 |
20.7 |
20.3 |
Table 2: Degradation of test item
Vessel no. |
% degradation |
|||||
0 h |
7 d |
14 d |
21d |
27 d |
28 d |
|
5 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
0 |
1 |
1 |
6 |
0 |
0 |
mean value |
0 |
1 |
1 |
3 |
0 |
0 |
Description of key information
83 % degradation (EU-method C.4-B) after 28 days.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The biodegradability of sodium p-chloro-m-cresolate (CAS 15733-22-9) was investigated in three biodegradation studies.
The key study investigated the ready biodegradability of sodium p-chloro-m-cresolate according to EU C. 4-B method (Modified OECD Screening Test). Activated sludge of a wastewater treatment plant was treated with the test item at a concentration of 9 mg/L DOC and incubated in the dark for 28 days. As test parameter the removal of dissolved organic carbon was measured. After 28 days a degradation of 83% was observed. Therefore, the test item can be considered as ready biodegradable.
In a supporting study the ready biodegradability of sodium p-chloro-m-cresolate was investigated according to EU C. 4-E method (closed bottle test. Activated sludge of a wastewater treatment plant was treated with the test item at a concentration of 5.13 mg/L and incubated in the dark. As test parameter the oxygen consumption was measured. Due to a degradation of 42% after 28 days in a pre-test the duration of the main test was conducted with an expanded test duration time of 56 days. At the end of the 56 days test duration a degradation of 18 % was observed.
Furthermore ready biodegradability of sodium p-chloro-m-cresolate was investigated according to EU C. 4 –B method (Modified OECD Screening Test. Activated sludge of a wastewater treatment plant was treated with the test item at a concentration of 18 mg/L and incubated in the dark for 28 days. As test parameter the removal of dissolved organic carbon was measured. After 28 days no degradation was observed.
It can be concluded that sodium p-chloro-m-cresolate is readily biodegradable under stringent test conditions, i.e., a high inoculum activity and/or the presence of appropriate inoculum species being able to degrade the substance. Hence, sodium p-chloro-m-cresolate can be considered to be ready biodegradable.
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