Phosphoric acid, 2-ethylhexyl ester, compd. with 2,2'-iminobis[ethanol]

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Version / remarks:

1989

Deviations:

yes

Remarks:

A 2000 mg/l test material solution was used and the third calibration standard was omitted in error from the run sequence.

Principles of method if other than guideline:

A 2000 mg/l test material solution was used instead of 1000 mg/l. However, as the sample was a 25% solution in water, this was necessary to achieve an effective concentration for OECD Guideline 117. In addition, the third calibration standard was omitted in error from the run sequence. The two preceding calibration standards were used to construct the overall calibration graph.

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

< 0

Remarks on result:

other: pH and temperature not provided

Details on results:

No peaks were detected using the Diode Array Detector. The Refractive Index Detector recorded one peak with a log Pow value of <0.

Conclusions:

The Refractive Index Detector recorded one peak for 25% M-528-7 (w/w) neutralised with DEA in deionised water, indicating a log Pow value of <0.

Executive summary:

An experiment was undertaken for 25% M-528-7 (w/w) neutralised with DEA in deionised water to determine its n-octanol-water partition coefficient. The study was compliant with GLP and performed according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). Two deviations from the guideline were reported, namely that a 2000 mg/l solution of the test material was prepared as opposed to 1000 mg/l. However, as the sample was a 25% solution in water, this was necessary in order to obtain an effective concentration. In addition, the third calibration standard was omitted in error from the run sequence and so the two preceding calibration standards were used to construct the overall calibration graph. No peaks were detected using the Diode Array Detector. However, one peak was observed for a log Pow value of <0 using the Refractive Index Detector. 25% M-528-7 (w/w) neutralised with DEA in deionised water was concluded to have a log Pow value of <0.

Description of key information

The Refractive Index Detector identified one peak with a log Pow value of <0 for 25% M-528-7 (w/w) neutralised with DEA in deionised water. This result was obtained in a GLP-compliant study performed according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method).

Key value for chemical safety assessment

Log Kow (Log Pow):

0