Registration Dossier
Registration Dossier
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EC number: 231-034-6 | CAS number: 7417-99-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
See also attached the chemical class information document. - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- The ECOSAR User Manual, ECOSAR. A Computer Program for Estimating the Ecotoxicity of Industrial Chemicals (EPA-748-R-93-002)
Estimating Toxicity of Industrial Chemicals to Aquatic Organisms Using Structure Activity Relationships (EPA-748-R-93-001).
ECOSAR v1.11 Methodology Document.
ECOSAR v1.11 Operation Manual. - Specific details on test material used for the study:
- SMILES: N1(C(=O)Nc2ccc(Cc3ccc(NC(=O)N4CC4)cc3)cc2)CC1
- Test organisms (species):
- Daphnia sp.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 10.313 mg/L
- Nominal / measured:
- estimated
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The daphnia 48-h LC50 for the test substance was predicted to be 10.313 mg/l (EPI-Suite, ECOSAR v1.11, substituted ureas).
- Executive summary:
The short-term toxicity to aquatic invertebrates of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The daphnia 48-h LC50 for the test substance was predicted to be 10.313 mg/l.
Reference
ECOSAR v1.11 class-specific estimation (substituted ureas) predicted that the test substance has a 48 h-LC50 to daphnia of 10.313 mg/L.
Description of key information
Key Study: Data from EPI-Suite, EPA (USA) / ECOSAR v1.11 class-specific estimation (substituted ureas). The test substance has been determined to have a 48-h LC50 to daphnia of 10.313 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10.313 mg/L
Additional information
Key Study: The short-term toxicity to aquatic invertebrates of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The daphnia 48-h LC50 for the test substance was predicted to be 10.313 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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