Dioleamide

Endpoint summary

Additional information

The target and source substance are anticipated to be hydrolyzed in the gastrointestinal tract and/or liver, resulting in the generation of primary fatty amines (oleylamine) as well as the corresponding long-chain saturated fatty acids (oleic and palmitic). Hydrolysis represents the first chemical step in the absorption, distribution, metabolism and excretion pathways assumed to be similar between the target substance and the source substance. Following hydrolysis of fatty acid amides, fatty acids are readily absorbed by the intestinal mucosa and distribute systemically in the organism. The resulting long-chain fatty acids oleic acid and palmitic acid are primarily degraded via mitochondrial β-oxidation and the breakdown products are finally metabolized for energy generation. The second hydrolysis product, the primary fatty amine (oleylamine) may be oxidatively deaminated by monoaminooxidases to yield the corresponding aldehyde and ammonia. The aldehyde may be further oxidized via the enzymatic action of aldehyde dehydrogenase to the corresponding carboxylic acid, which may be fed into further metabolic pathways such asb-oxidation. Ammonia resulting from the oxidative deamination of the hydrolysis product oleylamine is likewise readily absorbed and distributed within the body, especially in liver, where it is detoxified via the urea cycle. The resulting urea is transported to the kidneys, where it will either be re-absorbed and fed into physiological pathways, or directly excreted via urine.