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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 MAR 2021 to XX JUN 2022
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
GLP compliance:
yes (incl. QA statement)
Type of method:
spinning rotor
Temp.:
20 °C
Vapour pressure:
< 0 Pa

The offset value (mean DCR) was 7.2075 x 10-8 s-1 at 20°C.  This value was based on the average deceleration rate measured with an empty sample chamber.


The mean measured background vapor pressure of the system by the SRG method was  4.27x 10‑5 Pa at 20°C.


The mean measured vapor pressure of the reference substance, benzoic acid, by the SRG method was 6.12 x 10‑2 Pa at 20°C.  The vapor pressures were consistent with published values.


The system offset pressure using a molecular weight of 999 g/mol was 3.0993 x 10-5, while the calculated system offset pressure using a molecular weight of 598 and 1671 g/mol was 4.0059 x 10-5 Pa and 2.3964 x 10-5 Pa, respectively. 

Conclusions:
The vapor pressure of the sample and heated sample was determined at 20°C using the spinning rotor gauge (SRG) method. The mean measured vapor pressures of both samples at 20°C by the SRG method using molecular weights of 598 and 1671 g/mol were less than recommend range of the SRG method.
Executive summary:

The objective of this study was to experimentally determine the vapor pressure of the test item at 20 ± 1°C.


The test was performed based on procedures in the OECD Guideline 104 and the U.S. EPA Product Properties Test Guidelines, OPPTS 830.7950 according to GLP.


The vapor pressure of an aliquot test item and an aliquot of test item heated to between 60 and 70°C (to remove potential low molecular and volatile impurities from the synthesis process) for at least one hour was determined at 20°C using the spinning rotor gauge (SRG) method.  The mean measured vapor pressures at 20°C by the SRG method were less than the recommend range of the SRG method (10-4).


 

Description of key information

The objective of this study was to experimentally determine the vapor pressure of the test item at 20 ± 1°C.


The test was performed based on procedures in the OECD guideline 104 and the U.S. EPA Product Properties Test Guidelines, OPPTS 830.7950 according to GLP.


The vapor pressure of an aliquot test item and an aliquot of test item heated to between 60 and 70°C (to remove potential low molecular and volatile impurities from the synthesis process) for at least one hour was determined at 20°C using the spinning rotor gauge (SRG) method.  The mean measured vapor pressures at 20°C by the SRG method were less than the recommend range of the SRG method (10-4).

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information