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EC number: 240-343-5 | CAS number: 16215-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 3-mercaptopropionate
- EC Number:
- 220-912-4
- EC Name:
- Methyl 3-mercaptopropionate
- Cas Number:
- 2935-90-2
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- methyl 3-sulfanylpropanoate
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- head only
- Vehicle:
- air
- Remark on MMAD/GSD:
- n.a. for vapour
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 276, 350, 456, 493, and 529 ppm (mean measured), equivalent to 1.35, 1.72, 2.24, 2.42, and 2.60 mg/L, respectively
- No. of animals per sex per dose:
- 60
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 430 ppm
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.11 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- >= 1.89 - <= 2.25
- Exp. duration:
- 4 h
- Mortality:
- There were 25 deaths (12 males; 13 females) during the exposure period. There were no deaths during the 14-day observation period. The incidence of these deaths was exposure-level related, but there was no evident difference between the sexes. All animals died at the highest level, as shown below:
Measured Mortality Ratio
Conc.(ppm) Males:Females
Control 0/5:0/5
276 0/5:0/5
350 0/5:1/5
456 2/5:3/5
493 5/5:4/5
529 5/5:5/5 - Clinical signs:
- other: Chromodacryorrhoea was the main sign observed during and immediately following the exposure period in both test and control animals; it was considered to be attributable to the restraint procedure used in exposure. The few clinical signs observed in ani
- Body weight:
- A small temporary body weight loss in control and test animals was considered to be attributable to the procedure used for animal restraint.
- Gross pathology:
- There were no gross or histopathological evidence of target organ toxicity to account for the deaths.
The pathology of control and treated rats surviving to termination was unremarkable at necropsy or had minor findings such as uterine distension. Histopathology findings were also minor such as leucocyte foci in lung and liver and were consistent with the expected pattern of background pathology in rats of
this strain and age. There were no gross or histopathological findings suggestive of irreversible or delayed toxicity due to test article administration.
Any other information on results incl. tables
The exposure chamber temperature recorded for the control and treated groups ranged between 21 and 22 °C, and the chamber humidity was between 49 and 82%. The chamber air flow rates were in the range of 5.2 and 12.0 L/min. The oxygen concentration ranged between 20 and 21% for the control and treated animals throughout the study. The mean measured concentrations of MMP were 276, 350, 456, 493, and 529 ppm for the nominal concentrations of 396, 437, 682, 595, and 815 ppm, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The 4-h Inhalation LC50 of MMP as vapour is 430 ppm (2.11 mg/L).
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