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Oxidising properties

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Endpoint:
oxidising liquids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07.January.2008-04.March.2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study, guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.21 (Oxidising Properties (Liquids))
Deviations:
no
Principles of method if other than guideline:
Test objective
The objective of the test is to determine the oxidizing properties of a liquid test item.
Principle
The test item is mixed in a 1 to 1 ratio by weight with dried fibrous cellulose and introduced into a pressure vessel. If during mixing or filling spontaneous ignition occurs no further testing is necessary and the test item will be considered as an oxidizer. If no spontaneous ignition occurs, the mixture is heated in a pressure vessel and the mean time taken for the pressure to rise from 690 to 2070 kPa above atmospheric pressure
is determined. This is compared with the mean pressure rise time for a 1 to 1 mixture of the 66% w/w aqueous nitric acid solution and dried fibrous cellulose.
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
TEST ITEM
Identification LCE07102
Identification of the flask LCE07102, Req Nr: 24/07/00262/05,
Net: 2,500 L
Batch LCE07102
Expiry date Not provided
Supplier SEPPIC
Appearance Yellow liquid
Packaging 2 White opaque plastic flasks
Quantity received 2 x 1 Kg
Date of the reception December 12, 2007
Storage In darkness at room temperature
Identification number for the study 07-157

REFERENCE ITEM
Oxidizing properties liquids (A21)
Identification Nitric acid 66%
Supplier ACROS
Reference 124660010
Batch A0198010001
Expiry date of the reference item October 17, 2010
Periodicity of validation During each test
Results See the test for details
Conformity Yes
Contact with:
powdered cellulose
Duration of test (contact time):
ca. 3 d
Key result
Sample tested:
reference mixture with 65% nitric acid + cellulose (1:1 ratio)
Parameter:
mean pressure rise time
Result:
4 505 ms
Key result
Sample tested:
test mixture as specified
Parameter:
mean pressure rise time
Result:
33 147 ms

Mixture test item /cellulose

 Assay number  Reference item mass (g)  Cellulose mass (g)  Atmospheric pressure (kPa) Corrected pressure rise time (ms)  Mean corrected pressure rise time (ms)   Theoritical calculated min and max accepted value: +/- 30% of the mean pressure rise time (ms)
 2  2.4933  2.5002  98.4  35164  33147  [23203 ; 43091]
 3  2.4947  2.5041  98.6  41923  33147  [23203 ; 43091]
 4  2.4924  2.5020  98.6  38428  33147  [23203 ; 43091]
 10  2.5000  2.5026  98.8  25692  33147  [23203 ; 43091]
 11  2.5126  2.5052  98.9  24526  33147  [23203 ; 43091]

Mixture reference item/cellulose

ber  Reference item mass (g)  Cellulose mass (g)  Atmospheric pressure (kPa) Corrected pressure rise time (ms)  Mean corrected pressure rise time (ms)   Theoritical calculated min and max accepted value: +/- 30% of the mean pressure rise time (ms)
 1  2.4998  2.5042  98.3  4630  4505  [3153 ; 5857]
 2  2.5073  2.5028  98.4  3489  4505  [3153 ; 5857]
 3  2.5107  2.5068  98.5  4206  4505  [3153 ; 5857]
 4  2.5003  2.5009  98.8  4390  4505  [3153 ; 5857] 
 5  2.5003  2.5044  98.8  5811  4505  [3153 ; 5857]
Interpretation of results:
GHS criteria not met
Conclusions:
The mean pressure rise time obtained with the mixture reference item / cellulose was: 4505 ms.
The mean pressure rise time obtained with the mixture test item / cellulose was: 33147 ms.
The mean pressure rise time obtained with the mixture test item / cellulose was higher than the mean pressure rise time obtained with the mixture reference item.
The test item was not considered to have oxidizing properties in our experimental conditions.
Executive summary:

OXIDIZING PROPERTIES

In compliance with Commission Directive 2004/73/EEC

A21 method (2004)

AMENDMENTS

No amendment was requested.

DEVIATIONS

No incident which could have affected the quality or the interpretation of the results obtained was observed.

RESULTS

The mean pressure rise time obtained with the mixture reference item / cellulose was: 4505 ms.

The mean pressure rise time obtained with the mixture test item / cellulose was: 33147 ms.

The mean pressure rise time obtained with the mixture test item / cellulose was higher than the mean pressure rise time obtained with the mixture reference item.

The test item was not considered to have oxidizing properties in our experimental conditions.

Endpoint:
oxidising liquids
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE CATEGORY APPROACH
Registered substance (as identified in Section 1.1 identification) has similar chemical structure as the others members of the Category "Amino Acid Alkyl Amides, Sodium or
Potassium Salts" (the source chemicals).

The category “Amino Acid Alkyl Amides, Sodium or Potassium Salts” has been developed and evaluated to cover the assessment of the intrinsic properties of several similar
substances within the context of REACH Regulation. The Category includes sodium or potassium salts of amino acid alkyl amides, with a carbon chain length range of C6-C16 and an
aminoacidic pool of not selected aminoacids reflecting the natural distributions of aminoacids in various vegetables and cereals.


1. HYPOTHESIS FOR THE CATEGORY APPROACH (ENDPOINT LEVEL)
The Category has been built up considering the common chemical structure of its members. They are UVCB substances and they share the following features:
- they are salts of amino acid alkyl amides
- they are sodium or potassium salts
- the carbon chain length ranges between C6 and C16
- the carbon chain derives from cocoyl or lauroyl fatty acids
- the aminoacidic part of the molecules comes from a pool of aminoacids
- the aminoacids pool reflects the natural distributions of aminoacids in various vegetables and cereals.

Overall, the Category was formed on the hypothesis that substances sharing this common chemical structure can be considered analogues and can share intrinsic properties too. No
trends in properties is expected, except for those physicochemical properties depending on the carbon chain length.

2. CATEGORY APPROACH JUSTIFICATION
These substances share (i) eye damage and (ii) the absence of significant systemic toxicity.
Key result
Sample tested:
other: read-across approach
Remarks:
read-across approach
Parameter:
other: read-across approach
Remarks on result:
other: No oxidizing properties.
Remarks:
The registered substance is not considered to have oxidizing properties.
Conclusions:
Find below the oxidising properties result obtained for one similar substance (a comparable value is expected):

- The test item [similar substance 2] was not considered to have oxidizing properties in our experimental conditions.

The weight of evidence can be applied as the substances are very similar.
The registered substance is not considered to have oxidizing properties.
Executive summary:

The category “Amino Acid Alkyl Amides, Sodium or Potassium Salts” was formed on the hypothesis that substances sharing common chemical structure can be considered analogues and can share intrinsic properties too.

Based on this assumption, this property may be assessed using available data  for the category members.

The category has been assessed for members characterized by:

- sodium or potassium salts

- the carbon chain length ranges between C6 and C16

- the aminoacids pool reflects the natural distributions of aminoacids in various vegetables and cereals.

Description of key information

Key value for chemical safety assessment

Additional information

The registered substance is not considered to have oxidizing properties

Justification for classification or non-classification

Find below the oxidising properties result obtained for one similar substance (a comparable value is expected):

- The test item [similar substance 2] was not considered to have oxidizing properties in our experimental conditions.

The weight of evidence can be applied as the substances are very similar.

The registered substance is not considered to have oxidizing properties.