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Diss Factsheets
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EC number: 701-179-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 28 - Feb 17, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- (24 Feb 1987)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction products of fatty acids, C18 (unsaturated) alkyl with sulfur trioxide, potassium salts
- EC Number:
- 701-179-4
- Molecular formula:
- (C18H33)nO7K2S, n= 1-2
- IUPAC Name:
- Reaction products of fatty acids, C18 (unsaturated) alkyl with sulfur trioxide, potassium salts
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Octadecanoic acid, sulfo-, potassium salt
- Test item No.: 14/0449-1
- Physical state/appearance: liquid, brownish
- Analytical purity: 51.92%
- Homogeneity: homogeneous by visual inspection
- Stability: stable under storage conditions
- Expiry date: June 22, 2016
- Storage conditions: room temperature
- Lot/batch No.: 0012127444
- Density: 1.111 g/mL
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Additional strain characteristics: Crl:WI (Han)
- Source: Charles River Wiga GmbH, Sulzfeld, Germany
- Age at study initiation: approx. 8 weeks (males), 12 weeks (females)
- Mean weight at study initiation: approx. 240.6 g (males), 211.8 g (females)
- Housing: single housing in Makrilon cages type III
- Diet: VRF 1 (P) (SDS Special Diets Services, Altrip, Germany), ad libitum (analyses for chemical and microbial contaminants by the manufacturer was performed in quarterly intervals)
- Water: tap water, ad libitum (analyses was regularly performed by the municipal authorities of Heidelberg)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: about 40 cm² (dorsal and dorso-lateral parts of the trunk)
- % coverage: at least 10%
Fur was removed by clipping about 24 h before administration.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.29 mL/kg bw
- Concentration: 100%
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: shortly before administration, weekly thereafter and on the last day of observation
- Frequency of observations: several times on the day of administration and at least once daily thereafter each workday
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, scoring of skin findings Skin findings (according to Draize) - Statistics:
- Calculations were perfomred using Microsoft Excel 2003 and checked with a calculator.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No systemic clinical signs of toxicity were observed during clinical examination. Local skin effects at the application site comprised in one male animal well-defined erythema (grade 2) on study day 1, which decreased to very slight erythema (grade 1) fro
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals examined on the last day of observation.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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