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EC number: 476-890-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Oxidation reduction potential
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- Storage stability and reactivity towards container material
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- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Remarks:
- Essentiality of iron
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- The full list of bibliographical references cited in the justification for data waiving is provided in the Endpoint Summary of Section 5.3.1. When appropriate, Endpoint Study Records were created in the relevant IUCLID sections to reflect these bibliographical data (see the field "Cross-references" below).
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Data source
Reference
- Reference Type:
- publication
- Title:
- Novel insights into iron regulation and requirement in marine medaka Oryzias melastigma
- Author:
- Wang & Wang
- Year:
- 2 016
- Bibliographic source:
- Scientific Reports 6: 26615.
Materials and methods
- Principles of method if other than guideline:
- The study systematically investigated the Fe regulation and requirement in marine medaka. Briefly, the critical Fe requirements at different life stages (i.e., larval and female adult) were identified through whole body Fe content screen. A conventional 2-week feeding experiment was subsequently conducted to investigate their Fe regulation and requirement. Fe regulation was studied at both biokinetic and transcriptional levels at different time intervals over 2-week feeding experiment. Stage-dependent Fe requirement was determined based on these responses and quantified using universal applicable net Fe flux.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iron trichloride
- EC Number:
- 231-729-4
- EC Name:
- Iron trichloride
- Cas Number:
- 7705-08-0
- Molecular formula:
- FeCl3
- IUPAC Name:
- trichloroiron
- Details on test material:
- FeCl3.6H2O (> 99%, Sigma Aldrich).
Constituent 1
- Specific details on test material used for the study:
- Fe regulation and requirement in marine medaka were investigated by supplementing diets with FeCl3.6H2O (> 99%, Sigma Aldrich).
Results and discussion
Any other information on results incl. tables
Iron (Fe) is an essential trace element for marine fish. However, knowledge of Fe requirements at different development stages of marine fish is still limited. The publication reported the efficient Fe absorption strategies adopted by larval fish under different dietary Fe supplementary levels (i.e., 0–640 mg/kg). Biokinetically, the larval fish controlled their dietary Fe assimilation efficiency (AE, 1.6–18.5%), and enhanced their waterborne Fe uptake (ca. 2.5 fold change of uptake rate constant) once the dietary Fe was deficient (i.e., 27.4 mg Fe/kg feed). Transcriptionally, the expression of hepcidin1 (hep1; Fe regulator; i.e., 2.3–15.7 fold change) in larval fish was positively correlated with the Fe supplementary levels. Comparatively, the female adult fish were poor in assimilating the added Fe source (i.e., ferric form) with similar life-sustainable levels of Fe (i.e., 0.046–0.12 μg/g/d assimilated for Fe supplementary levels of 27.4, 162 and 657 mg Fe/kg feed).
Applicant's summary and conclusion
- Executive summary:
This publication contains data on the essentiality of iron and its regulation; which is part of the arguments used to waive the information requirement in Section 5.3.1 (Bioacumulation: aquatic / sediment).
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