Registration Dossier
Registration Dossier
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EC number: 213-668-5 | CAS number: 999-97-3
Water solubility
Administrative data
- Endpoint:
- water solubility
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data waiving: Data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The Merck Index Monograph ID M5995
Materials and methods
Results and discussion
- Details on results:
- Insol in water, reacts slowly.
HMDZ undergoes rapid hydrolysis in the presence of water; the half life at pH 7 and 1.5°C is <0.5 minutes. Based on the chemical structure of HMDZ, this hydrolysis is expected to produce ammonia (CAS No. 7664-41-7) and trimethylsilanol (CAS No. 1066-40-6). Ammonia was previously assessed in the OECD HPV Chemicals Programme. Because HMDZ is hydrolytically unstable, water solubility and partition coefficient were not measured; modeled values are provided. In aqueous solutions, exposures to HMDZ are likely to betransient and observed toxicity is likely due primarily to the hydrolysis products
Applicant's summary and conclusion
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