Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

water solubility
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data waiving: Data from handbook or collection of data

Data source

Reference Type:
review article or handbook
The Merck Index Monograph ID M5995

Materials and methods

Results and discussion

Details on results:
Insol in water, reacts slowly.

HMDZ undergoes rapid hydrolysis in the presence of water; the half life at pH 7 and 1.5°C is <0.5 minutes. Based on the chemical structure of HMDZ, this hydrolysis is expected to produce ammonia (CAS No. 7664-41-7) and trimethylsilanol (CAS No. 1066-40-6). Ammonia was previously assessed in the OECD HPV Chemicals Programme. Because HMDZ is hydrolytically unstable, water solubility and partition coefficient were not measured; modeled values are provided. In aqueous solutions, exposures to HMDZ are likely to betransient and observed toxicity is likely due primarily to the hydrolysis products

Applicant's summary and conclusion