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Administrative data

water solubility
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data waiving: Data from handbook or collection of data

Data source

Reference Type:
review article or handbook
The Merck Index Monograph ID M5995

Materials and methods

Results and discussion

Details on results:
Insol in water, reacts slowly.

HMDZ undergoes rapid hydrolysis in the presence of water; the half life at pH 7 and 1.5°C is <0.5 minutes. Based on the chemical structure of HMDZ, this hydrolysis is expected to produce ammonia (CAS No. 7664-41-7) and trimethylsilanol (CAS No. 1066-40-6). Ammonia was previously assessed in the OECD HPV Chemicals Programme. Because HMDZ is hydrolytically unstable, water solubility and partition coefficient were not measured; modeled values are provided. In aqueous solutions, exposures to HMDZ are likely to betransient and observed toxicity is likely due primarily to the hydrolysis products

Applicant's summary and conclusion