Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data waiving: Data from handbook or collection of data

Data source

Reference
Title:
SIAM 29, 20-22 October 2009, SIDS INITIAL ASSESSMENT PROFILE

Materials and methods

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
HMDZ was not irritating to the skin in rabbits in an OECD TG 404 study. In three 4-hr studies conducted under occlusive conditions according to U.S. Department of Transportation regulations, the substance caused necrosis of the skin; use of the occlusive cover is likely to have increased the severity of the effect. HMDZ was slightly or not irritating to the eyes in standard irritation studies (OECD TG 405 or similar) in animal tests