4-Ethoxy-2,3-difluoro-4'-methyl-1,1'-biphenyl

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-010-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Deviations:

no

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction

Deviations:

no

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

261 µm

St. dev.:

24

Key result

Percentile:

D50

Mean:

605 µm

St. dev.:

24

Percentile:

D90

Mean:

1 270 µm

St. dev.:

22

 The median particle size D50 (D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D50 = 624.9 µm

2nd test series: D50 = 585.9 µm

The average of the median particle size D50 was: D50 = 605 µm

 

The particle size D10 (D (v,0.1): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D10 = 280.4 µm

2nd test series: D10 = 242.4 µm

The average of the particle size D10 was: D10 = 261 µm

 

The particle size D90 (D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D90 = 1286 µm

2nd test series: D90 = 1254 µm

The average of the particle size D90 was: D90 = 1270 µm

 

The particle size distribution showed a maximum at approximately 600 µm. Additionally a shoulder / minor maximum was observed at approximately 100 µm.

 

The water solubility was determined to be 0.14 mg/L. This should have been low enough for a measurement in water. However all values from the second measurement showed a lower particle size. lt can therefore not be excluded that minor parts of the test item dissolved during the test. However as the measurements were nevertheless in good accordance to each other the result was evaluated as valid.

Conclusions:

The median particle sizes D10, D50 and D90 were determined to be 261 µm, 605 µm and 1270 µm, respectively.

Executive summary:

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item. The test item consisted of transparent spherical particles.Before the measurement two spatula points of the test item were mixed with demineralized water (with 1 % detergent) and homogenised.This homogenised dispersion was fed to the sample unit, which was filled with distilled water (with 1 % detergent). Subsequently the diluted dispersion was pumped to the optical system. After passing the analyser beam the sample was pumped back into the small volume sample dispersion unit. Two test series of three measurements each were performed. The measurement time was 12 s. The median particle sizes D10, D50 and D90 were determined to be 261 µm, 605 µm and 1270 µm, respectively.

Description of key information

The median particle sizes D10, D50 and D90 were determined to be 261 µm, 605 µm and 1270 µm, respectively.

Additional information

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item. The test item consisted of transparent spherical particles. Before the measurement two spatula points of the test item were mixed with demineralized water (with 1 % detergent) and homogenised. This homogenised dispersion was fed to the sample unit, which was filled with distilled water (with 1 % detergent). Subsequently the diluted dispersion was pumped to the optical system. After passing the analyser beam the sample was pumped back into the small volume sample dispersion unit. Two test series of three measurements each were performed. The measurement time was 12 s. The median particle sizes D10, D50 and D90 were determined to be 261 µm, 605 µm and 1270 µm, respectively.