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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-10-13 to 2018-12-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: Knudsen cell
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.002 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0.003 Pa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.096 Pa

The vapour pressure was measured in the overall temperature range of 20 °C to 120 °C (first measurement 50 °C to 120 °C, second measurement 20 °C to 40 °C). The measured vapour pressures at the corresponding temperatures are listed below. After the measurement a mass loss of approx. 100 % (w/w) (first measurement) and approx.1 % (second measurement) was determined.

 

Measured vapour pressures and corresponding temperatures

 

Temperature / °C

Vapour pressure / hPa

50

7.6x10E-4

60

3.4 x 10E-3

80

3.0 x 10E-2

90

2.8 x 10E-5

100

n.e.

110

n.e

120

n.e

20*

1.2 x 10E-5

25*

3.6 x 10E-5

30*

7.2 x 10E-5

35*

1.5 x 10E-4

40*

3.5 x 10E-4

30*

7.4 x 10E-5

n.e.: not evaluable; *second measurement

 

The data points measured above 90 °C could not be evaluated. The data point at 90 °C showed a decreasing tendency. lt was assumed that the vapour pressure at these temperatures led to a significantly increased evaporation. This is in accordance to a nearly empty test cell after the test. In order to exclude an influence on the data points at lower temperatures the measurement was repeated.

 

Antoine parameters and extrapolated vapour pressures

 

T/°C

p/hPa

log (p/hPa) = A +
B/(C+T[°C])

20

1.6 x 10E-5

A= 14.44975

25

3.3 x 10E-5

B= -5644.31

50

9.6 x 10E-5

C= 273.15

 

 

The following vapour pressure values for the test item were extrapolated from the experimental data

(vapour pressure: effusion method):

 

T/°C

p/hPa

p/Pa

20

1.6 x 10E-5

1.6x10*

25

3.3 x 10E-5

3.3 x 103

50

9.6 x 10E-5

9.6 x 102

 

Conclusions:
The vapour pressure of the test item was determined to be 1.6E-3 Pa at 20 °C, 3.3E-3 Pa at 25 °C and 9.6E-2 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 20 and 90 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be 1.6E-3 Pa at 20 °C, 3.3E-3 Pa at 25 °C and 9.6E-2 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 1.6E-3 Pa at 20 °C, 3.3E-3 Pa at 25 °C and 9.6E-2 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.003 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance (reference 4.6 -1). The vapour pressure of the test item was determined at temperatures between 20 and 90 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be 1.6E-3 Pa at 20 °C, 3.3E-3 Pa at 25 °C and 9.6E-2 Pa at 50 °C, respectively.

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