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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats.
Author:
Mishkinsky
Year:
1974
Bibliographic source:
Arch Int Pharmacodyn Ther. 1974 Jul;210(1):27-37.

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
pre guideline time, equvalent or similar to later OECD 401
GLP compliance:
no
Test type:
up-and-down procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methylpyridinio-3-carboxylate
EC Number:
208-620-5
EC Name:
1-methylpyridinio-3-carboxylate
Cas Number:
535-83-1
Molecular formula:
C7H7NO2
IUPAC Name:
1-Methylpyridinio-3-carboxylate
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
LD50 > 5000 mg/kg bw

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