Reaction mass of sodium methyl sulphate and 1-methylpyrodomop-3-carboxylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

publication

Title:

Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats.

Author:

Mishkinsky

Year:

1974

Bibliographic source:

Arch Int Pharmacodyn Ther. 1974 Jul;210(1):27-37.

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

pre guideline time, equvalent or similar to later OECD 401

GLP compliance:

no

Test type:

up-and-down procedure

Test material

Test material information

Constituent 1

Reference substance name:

1-methylpyridinio-3-carboxylate

EC Number:

208-620-5

EC Name:

1-methylpyridinio-3-carboxylate

Cas Number:

535-83-1

Molecular formula:

C7H7NO2

IUPAC Name:

1-Methylpyridinio-3-carboxylate

Test material form:

solid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

LD50 > 5000 mg/kg bw