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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Guideline:
other: Study from 1976 (no guidelines available at the time the study was performed).
Principles of method if other than guideline:
Draize test: 6 New Zealand Albino rabbits were dosed with 0.1 mL of undiluted TS over 24 hrs.
GLP compliance:
no
Remarks:
Study from 1976 (GLP was not compulsory at the time the study was performed).

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 1,3-diisopropylbenzene and 1,4-diisopropylbenzene
EC Number:
905-459-9
Molecular formula:
C12H18
IUPAC Name:
Reaction mass of 1,3-diisopropylbenzene and 1,4-diisopropylbenzene
Details on test material:
Lot/batch No.: XF 958

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
No further data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 mL of undiluted TS
Duration of treatment / exposure:
24 hrs
Observation period (in vivo):
168 hrs
Number of animals or in vitro replicates:
6
Details on study design:
No further data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24/48/72 h
Score:
3.2
Max. score:
110
Reversibility:
fully reversible within: 72 hrs
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
6 animals
Time point:
24/48/72 h
Score:
0
Max. score:
80
Remarks on result:
no indication of irritation
Irritation parameter:
iris score
Basis:
mean
Remarks:
6 animals
Time point:
24/48/72 h
Score:
0
Max. score:
10
Remarks on result:
no indication of irritation
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
6 animals
Time point:
24/48/72 h
Score:
4.8
Max. score:
20
Reversibility:
fully reversible within: 72 hrs
Remarks on result:
other: score=2x(Redness+Chemosis+Discharge) (no detail)
Irritation parameter:
chemosis score
Basis:
other: no data
Time point:
24/48/72 h
Remarks on result:
other: no details

Any other information on results incl. tables

Hours

1

24

48

72

120

168

Mean score (X/110)

10.3

6.6

3.0

0.0

0.0

0.0

Irritation score (24, 48, 72 hrs average): 3.2

Immediate: slight discomfort

10 min: slight to moderate erythema, copious discharge

1 h: slight to moderate erythema, very slight oedema, copious discharge

24 hrs: slight erythema, moderate to copious discharge

48 hrs: gradual improvement

72 hrs: all scored zero

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The TS was classified as slightly eye irritating (GHS criteria not met).
Executive summary:

In this older study (Draize test), 6 New Zealand Albino rabbits were dosed with 0.1 mL of undiluted TS over 24 hrs. The irritation score (24, 48, 72 hrs average) was given with 3.2/110 and the effects were fully reversible within 72 hrs. The TS was classified as slightly irritant to the eyes (GHS criteria not met).