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Registration Dossier
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EC number: 618-233-7 | CAS number: 890707-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8.11.19 - 16.3.2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181 CIPAC Handbook H (1998)
- Version / remarks:
- 1998
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Medium:
- other: p-xylene
- Solubility:
- < 10 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 33 - < 40 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- methanol
- Solubility:
- > 40 - < 50 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- acetone
- Solubility:
- > 160 - < 200 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- ethyl acetate
- Solubility:
- > 67 - < 80 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- dimethylformamide
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- DMSO
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Conclusions:
- 2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.
- Executive summary:
The solubility of 2 -Amino-5 -chloro-N,3 -dimethylbenzamide in several organic solvents is determined according to CIPAC MT 181 by adding successive measured volumes of solvent to a known mass of the test item until complete dissolution is observed. Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide was determind as followed:
- p-xylene lower than 10 g/L.
- dichloromethane between 33 g/L and 40 g/L.
- methanol between 40 g/L and 50 g/L.
- acetone between 160 g/L and 200 g/L.
- ethyl acetate between 67 g/L and 80 g/L
- dimethylformamide higher than 250 g/L.
- dimethylsulfoxide higher than 250 g/L.
as determien to
Reference
Description of key information
Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide in organic solvents was determined according to CIPAC 181 (1998).
2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.
Key value for chemical safety assessment
Additional information
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