2-Amino-5-Chloro-N,3-Dimethylbenzamide

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

8.11.19 - 16.3.2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 181 CIPAC Handbook H (1998)

Version / remarks:

1998

GLP compliance:

yes (incl. QA statement)

Key result

Medium:

other: p-xylene

Solubility:

< 10 g/L

Temp.:

20 °C

Key result

Medium:

other: dichloromethane

Solubility:

> 33 - < 40 g/L

Temp.:

20 °C

Key result

Medium:

methanol

Solubility:

> 40 - < 50 g/L

Temp.:

20 °C

Key result

Medium:

acetone

Solubility:

> 160 - < 200 g/L

Temp.:

20 °C

Key result

Medium:

ethyl acetate

Solubility:

> 67 - < 80 g/L

Temp.:

20 °C

Key result

Medium:

dimethylformamide

Solubility:

> 250 g/L

Temp.:

20 °C

Key result

Medium:

DMSO

Solubility:

> 250 g/L

Temp.:

20 °C

Test substance stable:

yes

Conclusions:

2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.

Executive summary:

The solubility of 2 -Amino-5 -chloro-N,3 -dimethylbenzamide in several organic solvents is determined according to CIPAC MT 181 by adding successive measured volumes of solvent to a known mass of the test item until complete dissolution is observed. Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide was determind as followed:

• p-xylene lower than 10 g/L.
• dichloromethane between 33 g/L and 40 g/L.
• methanol between 40 g/L and 50 g/L.
• acetone between 160 g/L and 200 g/L.
• ethyl acetate between 67 g/L and 80 g/L
• dimethylformamide higher than 250 g/L.
• dimethylsulfoxide higher than 250 g/L.

as determien to

Description of key information

Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide in organic solvents was determined according to CIPAC 181 (1998).

2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.