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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16.03.2021 - 26.03.2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2021
Report date:
2021

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
not specified
GLP compliance:
no
Type of method:
effusion method: Knudsen cell

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorobenzoic acid
EC Number:
200-805-9
EC Name:
4-chlorobenzoic acid
Cas Number:
74-11-3
Molecular formula:
C7H5ClO2
IUPAC Name:
4-chlorobenzoic acid
Test material form:
solid: particulate/powder
Details on test material:
white to yellowish crytalline powder

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.011 Pa

Any other information on results incl. tables

The vapour pressure was measured in the temperature range of 79 to 109 °C. The measured vapour pressure values together with the measured temperatures are listed in Table 2:

Table 2:    Results of the Effusion method

No.

Temperature / °C

Vapour pressure / Pa

1

79.5

0.34

2

89.5

0.99

3

94.5

1.61

4

99.4

2.68

5

104.5

4.25

6

109.4

6.76

The measured vapour pressure values in the temperature range of 94.5 to 109.4 °C are slightly outside of the measuring range of the effusion method. Since the vapour pressures could be recorded properly, these values are nevertheless used for evaluation.

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation can be derived by regression of the data points to

A = 16.0443

B = -5820.76

C = 273.15.

The vapour pressure of the test item calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No. 440/2008 Method A.4.Vapour Pressureand OECD Test Guideline 104 (2006) is shown inTable 3:

Table3:    Calculated vapour pressure values for 20, 25 and 50 °C

Temperature / °C

Vapour pressure / Pa

20

1.5 × 10-4

25

3.3 × 10-4

50

1.1 × 10-2

Applicant's summary and conclusion

Conclusions:
The vapor pressure of 4-Chlorobenzoic acid at 20°C, 25°C and 50°C is 0,00015 Pa, 0,00033 Pa and 0,011 Pa, respectively.
Executive summary:

The vapour pressure of the test item p-Chlorobenzoic acid was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No. 440/2008 Method A.4.Vapour Pressure and OECD Test Guideline No. 104 (2006).

Temperature / °C

Vapour pressure / Pa

20

1.5 × 10-4

25

3.3 × 10-4

50

1.1 × 10-2