2,6-dimethylpyridine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary literature

Data source

Reference

Reference Type:

other: Secondary literature

Title:

Acute oral toxicity of the test chemical 3-Picoline in rats.

Author:

U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS)

Year:

2009

Bibliographic source:

Hazard Characterization - Pyridine and Pyridine Derivatives Category, U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS), 2009.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

3-methylpyridine

EC Number:

203-636-9

EC Name:

3-methylpyridine

Cas Number:

108-99-6

Molecular formula:

C6H7N

IUPAC Name:

3-methylpyridine

Test material form:

liquid

Details on test material:

Substance name: 3-Picoline
CAS no.: 108-99-6
Mol. wt. 93.13
Smiles: CC1=CN=CC=C1
Physical state: Liquid
Purity: Not specified

Test animals

Species:

rat

Strain:

other: Fischer rats

Sex:

male

Details on test animals or test system and environmental conditions:

Not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

320, 630, 1300, 2000, 3200 or 5000 mg/kg-bw

No. of animals per sex per dose:

3 males/dose

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

630 mg/kg bw

Based on:

test mat.

Mortality:

50% mortality was observed at 630mg/kg bw

Clinical signs:

other: not specified

Gross pathology:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The lethal dose (LD50) value for acute oral toxicity test was considered to be 630 mg/kg bw,when rats were treated with test chemical orally.

Executive summary:

Acute oral toxicity study was performed in rats using test chemical 3 -Picoline (CAS no.: 108 -99 -6, E.C. no.: 203 -636 -9). 3 male rats per dose of Fischer strain were treated at a dose concentration 320, 630, 1300, 2000, 3200 and 5000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 14 days. Mortality in 50% of animal population was observed at dose 630 mg/kg bw. Hence, the LD50 value was considered to be 630mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.