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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary literature

Data source

Reference
Reference Type:
other: Secondary literature
Title:
Acute oral toxicity of the test chemical 3-Picoline in rats.
Author:
U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS)
Year:
2009
Bibliographic source:
Hazard Characterization - Pyridine and Pyridine Derivatives Category, U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS), 2009.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine
Test material form:
liquid
Details on test material:
Substance name: 3-Picoline
CAS no.: 108-99-6
Mol. wt. 93.13
Smiles: CC1=CN=CC=C1
Physical state: Liquid
Purity: Not specified

Test animals

Species:
rat
Strain:
other: Fischer rats
Sex:
male
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
320, 630, 1300, 2000, 3200 or 5000 mg/kg-bw
No. of animals per sex per dose:
3 males/dose
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
630 mg/kg bw
Based on:
test mat.
Mortality:
50% mortality was observed at 630mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The lethal dose (LD50) value for acute oral toxicity test was considered to be 630 mg/kg bw,when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in rats using test chemical 3 -Picoline (CAS no.: 108 -99 -6, E.C. no.: 203 -636 -9). 3 male rats per dose of Fischer strain were treated at a dose concentration 320, 630, 1300, 2000, 3200 and 5000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 14 days. Mortality in 50% of animal population was observed at dose 630 mg/kg bw. Hence, the LD50 value was considered to be 630mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.