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Administrative data

Description of key information

Skin sensitization:

The test material was considered to be not sensitizing to the skin.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Remarks:
Read across data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Guinea pig maximization test was conducted for test chemical to assess its skin sensitization potential in accordance with OECD Guideline 406
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified
Specific details on test material used for the study:
- Name of test material: Biphenyl
- Molecular formula: C12H10
- Molecular weight: 154.211 g/mol
- Smiles notation: c1(c2ccccc2)ccccc1
- InChl : 1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H
- Substance type: Organic
- Physical state: liquid
Species:
guinea pig
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
not specified
Route:
other: No data available
Vehicle:
not specified
Concentration / amount:
No data available
Day(s)/duration:
No data available
Adequacy of induction:
not specified
No.:
#1
Route:
other: No data available
Vehicle:
not specified
Concentration / amount:
No data available
Day(s)/duration:
No data available
Adequacy of challenge:
not specified
No. of animals per dose:
No data available
Details on study design:
No data available
Challenge controls:
not specified
Positive control substance(s):
not specified
Positive control results:
not specified
Reading:
1st reading
Group:
test chemical
Dose level:
No data available
No. with + reactions:
0
Clinical observations:
There was no evidence of any skin sensitization reaction.
Remarks on result:
no indication of skin sensitisation
Interpretation of results:
other: Not sensitizing
Conclusions:
The test material was considered to be not sensitizing to the guinea pigs’ skin.
Executive summary:

Guinea pig maximization test was conducted for chemical 1,1'-biphenyl (CAS no.: 92 -52 -4, E.C. no. 202 -163 -5) to assess its skin sensitization potential in accordance with OECD Guideline 406. Since the chemical did not induce any signs of contact sensitization, the test chemical was considered to be not sensitizing to the guinea pigs’ skin.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

Skin sensitization:

1. Guinea pig maximization test was conducted for chemical1,1'-biphenyl (CAS no.: 92 -52 -4, E.C. no. 202 -163 -5)to assess its skin sensitization potential in accordance with OECD Guideline 406. Since the chemical did not induce any signs of contact sensitization, the test chemical was considered to be not sensitizing to the guinea pigs’ skin.

2. Skin sensitizing test was conducted forNicotinonitrile (CAS no.: 100 -54 -9, E.C. no.: 202 -863 -0)in rabbit. Allergic effect was not observed in any of the animals. Hence the test substance was considered to be non sensitizing to rabbit skin.

Justification for classification or non-classification

Based on the studies available and weight of evidence the test substance was considered to be non-sensitizing.