Registration Dossier
Registration Dossier
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EC number: 203-587-3 | CAS number: 108-48-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
Data source
Reference
- Reference Type:
- other: Secondary literature
- Title:
- in vivo eye irritation study of 2-Picoline
- Author:
- U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS)
- Year:
- 2 009
- Bibliographic source:
- Hazard Characterization - Pyridine and Pyridine Derivatives Category, U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS), 2009
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Test material form:
- liquid
- Details on test material:
- Substance name: 2-Picoline
CAS no.: 109-06-8
Mol. wt.: 93.13
Smiles: CC1=CC=CC=N1
Physicl state: Liquid
Purity: Not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- not specified
- Number of animals or in vitro replicates:
- not specified
- Details on study design:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: conjunctival and corneal injury
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test substance was found to be irritating to the rabbit eye.
- Executive summary:
In vivo eye irritation study was performed in rabbits using test chemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). Rabbits were treated with the undiluted test chemical with and without washing. Animals were further observed for clinical signs of irritation. There was slight pain upon direct contact followed by severe conjunctival and corneal injury. The test substance was severely irritating to rabbit eye. Hence, the test chemical can be considered as "Category 2" according to the CLP.
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