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EC number: 203-587-3 | CAS number: 108-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin irritation:
The test substance was found to be irritating to the rabbit skin.
Eye irritation:
The test substance was found to be irritating to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Substance name: 2-Picoline
CAS no.: 109-06-8
Mol. wt.: 93.13
Smiles: CC1=CC=CC=N1
Physicl state: Liquid
Purity: Not specified - Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period:
- 4, 24 and 48 hours
- Number of animals:
- 6
- Details on study design:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test substance was found to be irritating to the rabbit skin.
- Executive summary:
In vivo skin irritation study was performed in rabbits using test chemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). 6 Albino rabbits were treated with the test chemical. Test chemical was administered dermally to the animals and were further observed for clinical signs of irritation at 4, 24 and 48 hours. Moderate erythema was observed. Hence, the test chemical can be considered as "Category 2" according to the CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- not specified
- Number of animals or in vitro replicates:
- not specified
- Details on study design:
- not specified
- Irritation parameter:
- other: conjunctival and corneal injury
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test substance was found to be irritating to the rabbit eye.
- Executive summary:
In vivo eye irritation study was performed in rabbits using test chemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). Rabbits were treated with the undiluted test chemical with and without washing. Animals were further observed for clinical signs of irritation. There was slight pain upon direct contact followed by severe conjunctival and corneal injury. The test substance was severely irritating to rabbit eye. Hence, the test chemical can be considered as "Category 2" according to the CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
1. In vivo skin irritation study was performed in rabbits using testchemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). 6 Albino rabbits were treated with the test chemical. Test chemical was administered dermally to the animals and were further observed for clinical signs of irritation at 4, 24 and 48 hours. Moderate erythema was observed. Hence, the test chemical can be considered as "Category 2" according to the CLP.
2. In vivo skin irritation study was performed in rabbits using testchemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). Rabbits were treated with the test chemical. Test chemical was administered dermally to the animals onto the intact and abraded skin. Animals were further observed for clinical signs of irritation. Severe burning was accompanied by severe hyperemia and moderate edema after single application.Severe scar with moderate scabbing remained after 21 days. The test item was severely irritating to rabbit skin. Hence, the test chemical can be considered as "Category 2" according to the CLP.
3. In vivo skin irritation study was performed in rabbits using testchemical 3 -Picoline (CAS no.: 108 -99 -6, E.C. no.: 203 -636 -9). 6 Albino rabbits were treated with the test chemical. Test chemical was administered dermally to the animals and were further observed for clinical signs of irritation. Irritation was observed. Hence, the test chemical can be considered as "Category 2" according to the CLP.
Eye irritation:
1. In vivo eye irritation study was performed in rabbits using testchemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). Rabbits were treated with the undiluted test chemical with and without washing. Animals were further observed for clinical signs of irritation. There was slight pain upon direct contact followed by severe conjunctival and corneal injury. The test substance was severely irritating to rabbit eye. Hence, the test chemical can be considered as "Category 2" according to the CLP.
2. The ocular irritation potential of 3-methylpyridine was assessed in rabbits. Undiluted 3-methylpyridine (CAS no.108 -99 -6, E.C. no.: 203 -636 -9)was applied to the eyes of male New Zealand albino rabbits and observed for signs of irritation till 7 or 14 days.Following 7 or 14 days rabbits were killed and histological examinations were performed on the eyes. Eye irritation was characterized by ocular irritation indices (OII). Eye irritation assessments showed that irritation was maximal either 1 hr or 1 day after exposure. Histological examination of the eyes showed keratitis lesions in corneal epithelial tissue, fibrillary edematous lamallae dissociation, and cellular inflammatory infiltration. Over longer periods of time, which included recovery, 3-methylpyridine was considered to be severely irritating to rabbit eyes and can be considered under "Category 2", as per the CLP criteria.
Justification for classification or non-classification
The skin and eye irritation potential of test chemical was observed in various studies. The results obtained from these studies indicate that the chemical is likely to cause skin and eye irritation. Hence the test chemical can be classified as "Category 2" irritant as per CLP.
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