Registration Dossier
Registration Dossier
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EC number: 200-836-8 | CAS number: 75-07-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
These data and information are based on the sources of the IUCLID Dataset from 19 February 2000 published by the European Commission and the International Programme on Chemical Safety (IPCS) published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization (Environmental Health Criteria 167).
Short description of key information:
Several studies for gene mutation, chromosomal damage and sister chromatid exchanges induced by acetaldehyde were reported.
Acetaldehyde is genotoxic in vitro, inducing gene mutations, clastogenic effects, and sister-chromatid exchanges (SCEs) in mammalian cells in the absence of exogenous metabolic activation. However, negative results were reported in adequate tests on Salmonella. Following intraperitoneal injection, acetaldeyhde induced SCEs in the bone marrow of Chinese hamsters and mice. However, acetaldehyde administered intraperitoneally did not increase the frequency of micronuclei in early mouse spermatids. There is indirect evidence from in vitro and in vivo studies to suggest that acetaldehyde can induce protein-DNA and DNA-DNA cross-links.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the data available, acetaldehyde is not classified according to 67/548/EEC (DSD) and 1272/2008/EEC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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